Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS
Figure 1
KS expression was induced in the spinal cords of SOD1G93A mice at end stage.
(A) Lumbar spinal cord lysates (24 weeks of age) were subjected to immunoblotting using anti-KS antibody (5D4) (n = 5). β-actin was used as the internal loading control. (B) Lumber spinal cord sections obtained from SOD1G93A mice and their age-matched non-Tg littermates were stained with anti-KS antibody. The lower panels are the highly magnified images of the regions marked with squares. Bars, 200 µm in upper panels; 50 µm in lower panels.