Interaction between Maternal and Offspring Diet to Impair Vascular Function and Oxidative Balance in High Fat Fed Male Mice
Figure 1
Phenotype of male mouse offspring at 15 and 30 weeks of age.
Dams were assigned to either a high fat (HF) diet or standard chow (C) for 4 weeks before conception and during gestation and lactation. At weaning, offspring were assigned to C or HF to give four dietary groups C/C, HF/C, C/HF and HF/HF. Bar graphs represent mean ± SEM for (A) Body weight from 15 week C/C n = 9, HF/C n = 8, C/HF n = 7, HF/HF n = 9 and 30 week C/C n = 10, HF/C n = 10, C/HF n = 10, HF/HF n = 10 offspring, and (B) Systolic blood pressure measured by tail-cuff plethysmography from 15 week and 30 week offspring (C/C n = 7, HF/C n = 7, C/HF n = 5, HF/HF n = 9). Statistical comparisons were by ANOVA for the effects of maternal and offspring diet and age (see Table 2) followed by analysis using post hoc Dunnett’s multiple comparison tests for HF/C, C/HF and HF/HF vs. C/C. Values significantly different between high fat fed offspring groups and control offspring (C/C) at 15 or 30 weeks of age are indicated by ** p<0.001.