Balance between MKK6 and MKK3 Mediates p38 MAPK Associated Resistance to Cisplatin in NSCLC
Figure 1
Lack of p38 MAPK activation correlates with resistance to CDDP.
A) Seven NSCLC cell lines were treated with the indicated doses of cDDP during 48 hours and viability was evaluated by the crystal violet method. Survival was referred to untreated cells. Bars indicate standard deviation (SD). B) All cell lines were exposed to the indicated doses of cDDP for 2 hours. Then samples were collected and 50 µg of the total cell lysate (TCL) were used to evaluate the p38MAPK phosphorylation levels by western blotting. Membranes were re-blotted against p38 as loading control.