A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy
Fig 1
Family based sample and study design.
Two sets of families were employed: those with T1R-affected offspring and those with leprosy but T1R-free offspring. The T1R-affected subset comprised 229 offspring belonging to 221 families while the T1R-free subset comprised 229 offspring in 209 families. Offspring were matched by clinical leprosy subtype in the two family sets. In a first analysis stage, the transmission disequilibrium test (TDT) was used to estimate significance of association of LRRK2 variants with disease in each subset. In a second stage, a formal heterogeneity test was performed to identify LRRK2 variants preferentially associated with T1R.