EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development
Figure 1
EmTIP: a T-cell immunomodulatory protein homologue from E. multilocularis.
(A) Alignment of EmTIP with human and mouse TIPs. Bioedit software, version 7.0.9, was used to align the amino acids sequences. Accession numbers for the sequences are as follows: EmTIP, HF912277; human TIP, Q8TB96; mouse TIP, Q99KW9. Identical residues are displayed in white on black background, biochemically similar residues in black on grey background. Gaps introduced to maximize the alignment are represented by dashes. Numbers at the end of each line correspond to the amino acid numbers in each respective sequence. EmTIP has 36% identity/48% similarity with Human TIP and 34% identity/42% similarity with Mouse TIP. The N-terminal signal sequences are shown in an open solid black box. Two FG-GAP repeats within EmTIP as predicted by SMART (http://smart.embl-heidelberg.de/) are shown within open solid red boxes. The C-terminal transmembrane domains are depicted in an open solid blue box. (B) Comparative structural architecture of E. multilocularis, human and mouse T-cell immunomodulatory proteins. Red boxes: signal sequences; Grey boxes: FG-GAP repeats; Blue boxes: Transmembrane domains. Sequence accession numbers are as described in (A), with structural architecture predicted with SMART (http://smart.embl-heidelberg.de/).