Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Fig 1
Kaplan–Meier estimates and Cox proportional hazard model fits from the ADGC Phase 1 case–control dataset, excluding NIA ADC and ADNI samples.
The proportional hazard assumptions were checked based on graphical comparisons between Kaplan–Meier estimations (dashed lines) and Cox proportional hazard models (solid lines). The 95% confidence intervals of Kaplan–Meier estimations are also demonstrated (shaded with corresponding colors). The baseline hazard (gray line) in this model is based on the mean of ADGC data. ADGC, Alzheimer’s Disease Genetics Consortium; ADNI, Alzheimer’s Disease Neuroimaging Initiative; NIA ADC, National Institute on Aging Alzheimer’s Disease Center; PHS, polygenic hazard score.