Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin
Figure 1
Meta-analysis of genome wide association studies for morning plasma cortisol.
A) Manhattan plot of −lop10P values by chromosome. The red horizontal line indicates genome-wide significance (P<5×10−8) and the blue horizontal line indicates moderate significance (P<5×10−5). The lead SNP rs12589136 (chr14:94,793,686; b37) in red is genome-wide significant. SNPs within ±50 kb of cortisol-related candidate genes (listed in Table S6) are highlighted in colours. B) Quantile-quantile plot of −log10P, comparing the distribution of observed −log10P-values and that expected by chance.