Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis
Fig 1
Associations between clinical symptoms and DMN connectivity.
The correlation between adjusted DMN connectivity with the PCA components in A and B, and between adjusted DMN connectivity with FSS and BDI continuous scores in C and D. The grey tones for each subject represent clinical categories in C and D as described and shown in Table 1, and individual subject scores in A and B. (A) Increased PCA1 (high burden of both fatigue and depression) is positively correlated with DMN connectivity. (B) Decreased PCA2 (low burden of fatigue and high burden of depression) is negatively correlated with DMN connectivity. (C) Mean FSS correlated with DMN connectivity. (D) BDI sum scores correlated with DMN connectivity. Shown in E is the DMN component from the group independent component analysis (gICA). The component z-statistic map was thresholded at z>4. Depicted in three axial slices the posterior cingulate cortex (PCC) and the medial prefrontal cortex (mPFC) are masked out in red and yellow colours bilaterally.