Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120
Fig 1
Maximum likelihood phylogenetic tree including 774 envelope gp120 nucleotide sequences.
Sequences from HVTN 505 vaccine (in red) and placebo (in blue) recipients (n = 486) are depicted along with 288 HIV-1 subtype B sequences from the US and sampled since 2005. Sequences from two vaccine recipients who were each dually-infected (with two independent strains) are highlighted with orange and magenta shading. Subjects with multiple founder variants are highlighted with yellow shading.