Epigenome-Wide DNA Methylation in Hearing Ability: New Mechanisms for an Old Problem
Figure 1
Manhattan Plot of PC1 EWAS results.
The manhattan plot depicts the significance of association with PC1 as the negative logarithm of the p-value (-log(p-value)) versus the chromosomal location (chromosomes) for each of the 24,641 tested DNA-methylation probes. The red line defines a Bonferroni adjusted genome-wide suggestive significance threshold of p = 6.9×10−6. The ten most highly associated probes are located above the horizontal blue line corresponding to p<6.985×10−5.