Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat
Figure 1
Kupffer cells were depleted by treatment with Lip-Clod.
ED1 immunostaining of rat liver sections (A, B and C, ×200). ED2 immunostaining of rat liver sections (D, E and F, ×200). ED1 (A) and ED2 (D) positive cells could be easily identified in sinusoidal areas in control rats. Only a few ED1 positive cells could be observed 2 days after Lip-Clod administration (B). Some small ED1 positive cells appeared 6 days after PH (C). Arrows point to positive cells. Treatment with Lip-Clod resulted in a nearly complete elimination of ED2 positive Kupffer cells 2 days after Lip-Clod administration (E). Few ED2 positive cells could be identified 9 days after PH (F). Bar = 50 µm.