Geographical distribution and genetic diversity of Plasmodium vivax reticulocyte binding protein 1a correlates with patient antigenicity
Fig 1
Schematic diagram of PvRBP1a and protein tertiary structure prediction.
The region of PvRBP1a was divided based on specific features domain, polymorphism patterns, and structure homology between PvRBP2b and PvRBP1a. (A) PvRBP1a fragments were divided into six regions, and each fragment nucleotide diversity (π) is shown on the upper panel. The schematic diagram shows a black box indicating signal peptide, and the green box is the transmembrane domain. The structural homology domain (head and tail) with PvRBP2b is indicated by amino acid position (aa.). PvRBP1a-N and PvRBP1a-C positions indicate recombinant antigen position. (B) The predicted structure of PvRBP1a (152–625 aa.) showed highly similar structures with PvRBP2b (168–633 aa., PDB ID: 6d03.1) when considering the superimposition between them based on Z-score (38.8) and RMSD (0.6 Å).