Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes
Fig 1
Cladogram of cestode and invertebrate serotoninergic GPCRs.
The amino acid sequences of predicted cestode serotonin receptors were aligned with the repertoire of serotonin receptors cloned from various other flatworm and non-flatworm invertebrate model organisms; Dugesia japonica, 5-HTDj; Schistosoma mansoni, 5-HTSm; Caenorhabditis elegans, 5-HTCe; Drosophila melanogaster, 5-HTDm. The cestode GPCR sequences cloned and functionally expressed in this study (5-HT7Egran1, 5-HT7Egran2, 5-HT7Mco1) cluster within a clade of 5-HT7 like receptors (green), as does an additional predicted M. corti sequence (5-HT7Mco2). Other predicted cestode serotoninergic sequences (5-HT1Egran1 and 5-HT1Egran2) cluster within a clade of 5-HT1 like receptors (blue). See methods for complete list of UniProt and GenBank sequence identifiers used in this analysis. Analysis was bootstrapped with 500 replicates.