Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses
Figure 1
Egg and daughter sporocyst parasite stages display the most divergent transcriptional profiles within the Schistosoma lifecycle.
Correlations of M (log2 (Alexafluor647/Alexafluor555)) ratio values between intra- (lifecycle replicate) and inter- (life-stage comparison) parasite samples were calculated. A heatmap of the correlations, calculated on data normalised within each DNA microarray, is illustrated. Red represents a high correlation and blue depicts a low or lower correlation. Un-scaled data were clustered by Euclidean distance and shown as dendrograms above and to the left of the heatmap. * Indicates female sample replicate manually removed.