Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development
Figure 1
Mouse Lung Development Profiles in Temporal PC Representation, and the General Developmental Profile Segregation of Up- and Down-Regulated Genes in Human Lung Cancer
(A) Expression profiles of all 3,590 unique genes during mouse lung development as represented in temporal PC1 and PC2. Each dot marks a gene.
(B) Developmental profile examples of genes at the periphery of the disc-like scatter plot in (A) at 45° (π/4 radians starting at “3 o'clock”) rotational intervals.
(C) Histograms of the mouse lung temporal PC1 coordinates of the 719 genes 2-fold significantly up- and down-regulated in any one of the four human lung cancer subtypes (χ2 = 168.338, p < 0.001, OR = 8.652).
(D) The profiles of the top 100 genes (68 cancer up-regulated [green circles] and 32 cancer down-regulated [magenta circles]) composing the malignancy signature (see Results) among all 3,590 mouse lung developmental gene profiles. Of the 68 cancer up-regulated genes, all but two are in the late developmental profile hemisphere. Of the 32 cancer down-regulated genes, all but two are in the early developmental profile hemisphere (χ2 = 82.5185, p < 0.001, OR = 544).