Two-Stage Two-Locus Models in Genome-Wide Association
Figure 1
Power to Detect Association for 1,500 Individuals where Both Loci Are Responsible for 5% of the Trait Variance
Power is displayed on the vertical axis, allele frequencies at both loci on the horizontal axes. Results are shown for an (A) additive model where there is no epistasis (MA), (B) a simple looking epistatic model (M27) in which an individual requires at least one copy of the increaser allele at both loci in order to increase the quantitative phenotype above baseline levels, and (C) a more exotic model where an individual has to be heterozygous at both loci in order to have a trait mean above baseline (M16).