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Zink: Pathophysiologische Effekte, Mangelzustände und Wirkungen einer Supplementierung bei älteren Personen – ein Forschungsüberblick*

Zinc: Pathophysiologic effects, nutritional deficiency, and effects of supplementation in older people – a review

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Summary

Zinc is an essential micronutrient. Several studies have shown that zinc deficiency is common in older people. Zinc has been extensively studied with regard to its role in wound healing, infections, immune system, cardiovascular disease, and several other medical conditions. Several investigators have published intervention studies using zinc supplements in older people with favorable outcomes. This paper will briefly review the pathophysicologic effects of zinc, nutritional deficiency, and effects of zinc supplementation in older people.

Zusammenfassung

Zink ist ein essentieller Nährstoff. Verschiedene Studien haben gezeigt, daß Zinkmangel bei älteren Personen häufig vorkommt. Die Bedeutung von Zink für die Wundheilung, Infektionen, das Immunsystem, kardiovaskuläre Erkrankungen und verschiedene andere Zustände ist ausgiebig untersucht worden. Verschiedene Forscher haben Interventionsstudien mit Zink-Supplementen bei älteren Personen mit günstigen Resultaten veröffentlicht. Diese Arbeit soll einen kurzen Überblick über die pathophysiologischen Effekte von Zink, Zink-Mangelzustände und Wirkungen einer Zink-Supplementierung bei älteren Personen geben.

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Literatur

  1. Abbasi AA, Rudman D (1994) Undernutrition in the Nursing Home: Prevalence, Consequences, Causes and Prevention. Nutr Rev 52 (4):113–122

    Google Scholar 

  2. Agren MS (1990) Studies on zinc in wound healing. Acta Derm Venerol (Suppl) 154:1–36

    CAS  Google Scholar 

  3. Bogden JD, Bendich A, Kemp FW, Bruening KS, Skurnick JH et al. (1994) Daily micronutrient supplements enhance delayed-type hypersensitivity skin test responses in older people. Am J Clin Nutr 60 (3):437–447

    PubMed  CAS  Google Scholar 

  4. Boukaiba N, Flament C, Acher S, Chappuis P, Piau A et al. (1993) A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am J Clin Nutr 57 (4):566–572

    PubMed  CAS  Google Scholar 

  5. Chandra RK (1992) Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340:1124–1137

    Article  PubMed  CAS  Google Scholar 

  6. Chandra RK (1984) Excessive intake of zinc impairs immune response. JAMA 252:1443–1446

    Article  PubMed  CAS  Google Scholar 

  7. Chavance M, Herbeth B, Lemoine A, Zhu BP(1993) Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled Trial. Internat J Vitam Nutr Res 63:11–16

    CAS  Google Scholar 

  8. Clayton RJ (1972) A Double-blind trial of oral zinc sulfate in patitnets with leg ulcers. J Clin Pract 26:368–370

    CAS  Google Scholar 

  9. Dachowski EJ, Plummer VA, Greaves VM (1975) Venous leg ulceration: skin oil serum zinc concentrations. Acta Derm Venerol 55:497–498

    PubMed  CAS  Google Scholar 

  10. Constantinidis J (1991) The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles. Med Hypoth 35:319–323

    Article  CAS  Google Scholar 

  11. Fortes C, Forastiere F, Agabiti N, Fano V, Pacifici R, Virgili F, Piras G et al. (1998) The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 46:19–26

    PubMed  CAS  Google Scholar 

  12. Girodon F, Lombard M, Golan P, Brunet- Leconte P, Monget A, Arnaud J et al. (1997) Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 41:98–107

    Article  PubMed  CAS  Google Scholar 

  13. Hallbook T, Lanner E (1972) Serum zinc and healing of venous leg ulcers. Lancet ii 780–782

  14. Hartz SC, Russell RM, Rosenberg IH (eds) (1990) Nutrition in the elderly: The Boston Nutritional Status Survey. London: Smith-Gordon

  15. Heyneman CA (1996) Zinc deficiency and taste disorders. The annals of Pharmacotherapy 30:186–187

    PubMed  CAS  Google Scholar 

  16. Hiller R, Seigel D, Sperduto D, Blair N, Burton T (1995) Serum zinc and serum lipid profiles in 778 adults. Ann Epidemiol 5:490–496

    Article  PubMed  CAS  Google Scholar 

  17. Krasinski SD, Russell RM, Samloft JM, Jacob RA et al. (1986) Fundic atrophic gastritis in an elderly population: effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc 34:800–806

    PubMed  CAS  Google Scholar 

  18. Mares-Perlman JA, Klein R, Klein B, Greger JL, Brady WE, Palta M, Ritter LL (1996) Association of zinc and antioxidant nutrients with age related maculopathy. Arch Ophthalmol 114:991–997

    PubMed  CAS  Google Scholar 

  19. Mobarhan S, Trumbore LS (1992) Nutritional problems of the elderly. Clinics in Geriatr Med 7 (2):191–214

    Google Scholar 

  20. Monget AL, Galan P, Presiosi P, Keller H, Bourgeois C et al. (1996) Micronutrient status in elderly people. Internat J Vit Nutr Res 66:71–76

    CAS  Google Scholar 

  21. Niedner R, Wokalek H, Schopf E (1986) Influence of zinc on the healing of wounds. Z Hautkr 61:741–742

    PubMed  CAS  Google Scholar 

  22. Norman JN, Rahmat A, Smith G (1975) Effects of supplements of zinc salts on the healing of granulating wounds in the rat and guinea pig J Nutr 105:815–821

    PubMed  CAS  Google Scholar 

  23. Phillips A, Davidson M, Greaves MW (1977) Venous leg ulceration: evaluation of zinc treatment, serum zinc and rate of healing. Clin Exp Dermatol 2:395–399

    Article  PubMed  CAS  Google Scholar 

  24. Pike J, Chandra RK (1995) Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Internat J Vit Nutr Res 65:117–120

    CAS  Google Scholar 

  25. Reunanen A, Knekt P, Marniemi J, Maki J, Maatela J, Aromaa A (1996) Serum calcium, magnesium, copper, and zinc and risk of cardiovascular death. European J Clin Nutr 50:431–437

    CAS  Google Scholar 

  26. Rudman D, Abbasi AA, Isaacson K, Karpuik E (1995) Observations on the nutrient intakes of eating dependent nursing home residents: underutilization of micronutrient supplements. J Am Coll Nutr 14 (6):604–613

    PubMed  CAS  Google Scholar 

  27. Santos-Neto L, Tosta CE, Dorea JG (1992) Zinc reverses the increased sensitivity of lymphocytes from aged subjects to the antiproliferative effect of prostaglandin E2. Clinical Immunology Immunopathology 64 (3):184–187

    Article  CAS  Google Scholar 

  28. Stafford W, Smith RG, Lewis SJ, Henery E, Stephen PJ et al. (1998) A Study of zinc status of elderly institutionalized patients. Age & Ageing 17:42–48

    Article  Google Scholar 

  29. Tully CL, Snowdon DA, Markesbery WR (1995) Serum zinc, senile plaques, and neurofibrillary tangles: Findings from the nun study. Neuroloreport 6:2105–2108

    Article  CAS  Google Scholar 

  30. Wood R (1990): Zinc In Hartz SC, Russell RM, Rosenberg IH (eds) Nutrition in the Elderly: The Boston Nutritional Status Survey London: Smith-Gordon

  31. Yoshida S, Endo S, Tomita H (1991) A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris-Nasus Larynx 18:153–161

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, WI 53226, USA

    A. Abbasi &  K. Shetty

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  1. A. Abbasi
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  2. K. Shetty
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*Aus dem Englischen übersetzt von Ernst Grell, lic. phil., Maiengasse 25, CH-4056 Basel, Schweiz

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Abbasi, A., Shetty, K. Zink: Pathophysiologische Effekte, Mangelzustände und Wirkungen einer Supplementierung bei älteren Personen – ein Forschungsüberblick*. Z Gerontol Geriat 32 (Suppl 1), S75–S79 (1999). https://doi.org/10.1007/s003910050184

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