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Research on the therapeutics of intense abdominal irradiations in pigs

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Summary

Tests of surgical treatments (graft of small intestine, and partial enter ectomy before or after irradiation) and dietetic treatments (continuous parenteral feeding) were carried out on 80 pigs irradiated over the posterior half of the body with doses of between 950 and 1750 rad at mid plane.

The results relate to clinical symptoms, survivals, haematology, and histopathology; nutritional aspects were studied by means of evaluation of balances (nitrogen, lipids, and minerals) and absorption tests (58Co - Vit. B 12 and iodised lipids).

Above 1200 rad recuperation of the digestive system did not in general make prolonged survival possible; in addition to intestinal lesions, renal and especially pancreatic atrophy appeared, whose consequences appeared to be determinative as regards the nutrition and hence the survival of the animals.

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References

  1. Anonymous: Vascular problem following whole-body irradiation. Final Report - NYO - 1680 -June 1964

  2. Bailenger, J., Clyti, B., Le Hir, A.: Analyse chimique des selles. Arch. Fr. Mal. App. Dig.45, 45 (1956)

    Google Scholar 

  3. Birge, S. J., Alpers, D. H.: Stimulation of intestinal mucosai proliferation by vitamin D. Gastroenterology64, 977–982 (1973)

    Google Scholar 

  4. Chomette, G., Daburon, F., Auriol, M., Garnier, H.: Irradiation à forte dose de l'intestin grêle chez le porc. Etudes histoenzymologique et ultrastructurale. Virchows Arch. B. Cell. Path.23, 237–256 (1977)

    Google Scholar 

  5. Colin, J., Polonovski, C.: Techniques d'exploration de l'appareil digestif. In: Explorations biologiques en pédiatrie, 2nd ed., Paris: Expansion Scientifique Française 1963

    Google Scholar 

  6. Corring, T., Daburon, F., Remy, J.: Effet de l'irradiation aiguë sur la secrétion du pancréas exocrine chez le porc. Strahlentherapie149, 417–425 (1975)

    Google Scholar 

  7. Corring, T., Bourdon, D.: Exclusion of pancreatic exocrine secretion from intestine in the pig: Existence of a digestive compensation. J. Nutr.107, 1216–1221 (1977)

    Google Scholar 

  8. Daburon, F., Remy, J., Nizza, P.: Etude du syndrome gastro-intestinal d'irradiation chez le porc. Strahlentherapie144, 343–361 (1972)

    Google Scholar 

  9. Daburon, F.: Le syndrome gastro-intestinal d'irradiation. Revue Bibliographique. Etude particulière chez le porc. Rapport CEA - R-4506, 1973

  10. Daburon, F., Chomette, G., Garnier, H., Remy, J., Villiers, R. A., Nizza, P.: Experimental treatment of pigs irradiated on the abdomen with supralethal doses. Strahlentherapie146, 718–733 (1973)

    Google Scholar 

  11. Daburon, F., Chomette, G., Remy, J., Villiers, P. A., Gregond, J. C., Tricaud, Y., Sevignac, M., Haag, J.: La restauration de l'intestin chez le porc irradié à forte dose. Données enzymologiques, histologiques et fonctionnelles. Biol.-Gastroenterol (Paris)8, 321–338 (1975); Supplément No. 4 aux Arch. Fr. Mal. App. Dig.64 (1975)

    Google Scholar 

  12. Daburon, F., Duee, P. H.: Nutritional and clinical aspects of parenteral nutrition in pigs irradiated on the abdomen with supralethal doses. Biomedicine-Express25, 385–389 (1976)

    Google Scholar 

  13. Daburon, F., Duee, P. H., Tricaud, Y., Bourhoven, D., Marion, C.: Bilans nutritionnels chez le porc irradié à forte dose (1100 rd) sur la moitié postérieure de corps. Ann. Biol. Anim. Biochem. Biophys.18, 651–662 (1978)

    Google Scholar 

  14. Eddy, H. A., Casarett, G. W.: Intestinal vascular changes in the acute radiation intestinal syndrome. In: Gastro-intestinal radiation injury. Sullivan, M. F. (ed.), p. 385–395. Excerpta Medica Foundation 1968

  15. Eddy, H. A., Casarett, G. W.: Urine output, saline intake and adrenal factors after lethal-whole body or intestinal irradiation. Radiat. Res.37, 287–298 (1969)

    Google Scholar 

  16. Fitzpatrick, P. J., Rider, W. D.: Half body radiotherapy. Int. J. Rad. Oncol. Biol. Phys.1, 197–207 (1976)

    Google Scholar 

  17. Hamilton, E.: Differences in survival of mouse colon cryptes after whole or partial-body irradia tion. Int. J. Radiat. Biol.31, 341–347 (1977)

    Google Scholar 

  18. Handford, S. W., Johnson, P. W., Scholjes, R. J., Duny, M. J.: The small intestine in acute radiation death in the dog. Radiat. Res.15, 734–744 (1961)

    Google Scholar 

  19. Hay, J. M., Fagniez, P., Villiers, P. A., Garnier, H.: Une technique de transplantation hétérotopique de l'intestin grêle chez le porc: la Transplantation réno-mésentérique. J. Chirurg. (Paris)110, 373–377 (1975)

    Google Scholar 

  20. Kingham, J. G. C., Loehry, C. A.: Permeability of the small intestine after intra-arterial injection of histamine - Type mediators and irradiation. Gut17, 517–526 (1976)

    Google Scholar 

  21. Krause, P., Ziegler, K.: Experimentelle Untersuchungen über die Einwirkung der Röntgenstrahlen auf tierisches Gewebe. Fortschr. Röntgenstr.10, 126 (1906)

    Google Scholar 

  22. Kunlin, A., Hay, J. M., Fagniez, P. L., Parc, R., Steiner, P., Clot, J. P., Garnier, H.: Technique de transplantation orthotopique de l'intestin grêle chez le porc. Ann. Chir.26, 505–510 (1972)

    Google Scholar 

  23. Lelong, M., Colin, J., Polonovski, C.: Les steatorrhées infantiles - Leur caractérisation. Arch. Fr. Pédiatr.10, 561–586 (1953)

    Google Scholar 

  24. Lesher, J., Lesher, S.: Effects of single dose partial body X-irradiation on cell proliferation in the mouse small intestinal epithelium. Radiat. Res.57, 148–157 (1974)

    Google Scholar 

  25. Maas, J., Vaiman, M., Gaillard, H., Nizza, P., Chenut, C.: Repartition de la moelle osseuse dans le squelette du porc. Application à l'irradiation partielle à dose létale. Strahlentherapie144, 457–476 (1972)

    Google Scholar 

  26. Meslin, J. C., Daburon, F.: Durée de renouvellement de l'épithélium intestinal chez le porc adulte selon deux modes d'administration de la thymidine tritiée. Ann. Biol. Anim. Bioch. Biophys.17, 33–41 (1977)

    Google Scholar 

  27. Nesterenko, W. S., Bandurko, L. N., Cherkasov, V. F., Brodskil, R. A.: Change in radiation lesions of the intestine under the influence of sodium citrate and heparin. Radiobiologiya (URSS)13, 280–283 (1973)

    Google Scholar 

  28. Osborne, J. W.: Modification of intestinal radiation death by surgical means. Radiat. Res.17, 22–33 (1962)

    Google Scholar 

  29. Pageau, R., Bounous, G.: Systematic protection against radiation. III. - Increases intestinal radioresistance in rats fed a formula-defined diet. Radiat. Res.71, 622–627 (1977)

    Google Scholar 

  30. Quastler, H.: The nature of intestinal radiation death. Radiat. Res.4, 303–320 (1956)

    Google Scholar 

  31. Regaud, C., Nogier, T., Lacassagne, A.: Sur les effets redoutables des irradiations étendues de l'abdomen et sur les lésions du tube digestif déterminées par les rayons de Roentgen. Arch. Electr.21, 321 (1912)

    Google Scholar 

  32. Remy, J., Daburon, F., Villiers, P. A., Dubedat, P.: Effets de l'irradiation aiguë à dose létale sur la secrétion gastrique chez le porc. Strahlentherapie150, 532–538 (1975)

    Google Scholar 

  33. Rubin, P., Casarett, G. W.: Radiation histopatology. In: Clinical radiation pathology, vol. 1, pp. 38–61. Philadelphia: Saunders 1968

    Google Scholar 

  34. Saenger, E. L., Silberstein, E. B., Horwitz, Kereiakes, J. G., Bahr, G. K., Perry, H., Friedman, B. L: Whole body and partial body radiotherapy of advanced cancer. Am. J. Roent. Rad. Therap. Nucl. Sci.117, 670–685 (1973)

    Google Scholar 

  35. Schilling, R. F.: Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J. Lab. Clin. Med.42, 860–866 (1953)

    Google Scholar 

  36. Sigdestad, C. P., Osborne, J. W.: The influence of prior intestinal resection on survival time of intestine-irradiated rats. Int. J. Radiat. Biol.15, 65–73 (1969)

    Google Scholar 

  37. Steckel, R. S., Snow, H. D., Collins, J. D., Barenfus, M., Patin, T.: Successful radiation protection of the normal intestinal tract of the dog. Radiology111, 451–455 (1974)

    Google Scholar 

  38. Sullivan, M. F., Hackett, P. L., Marks, S.: U.S. Report HW-47500, pp. 46–54 (1958)

  39. Vaiman, M., Dubiez, R., Colson, X., Nizza, P.: Autogreffes de moelle osseuse chez des porcs irradiés à doses létales. Int. J. Rad. Biol.14, 207–224 (1968)

    Google Scholar 

  40. Vaiman, M., Garnier, H., Kunlin, A., Hay, J. M., Pare, R., Bacour, F., Fagniez, P. H., Villiers, P. A., Lecointre, J., Bara, M. F.: The SLA histocompatibility system in the SUS SCROFA species. Transplantation14, 541–550 (1972)

    Google Scholar 

  41. Warren, S., Friedman, N. B.: Pathology and pathological diagnosis of radiation lesions in the gastro-intestinal tract. Am. J. Pathol.18, 499–513 (1942)

    Google Scholar 

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Authors and Affiliations

  1. Département de Protection - Commissariat à l'Energie Atomique, Laboratoire de Radiobiologie Appliquée, B.P. 2, F-91190, GIF-Sur-Yvette

    F. Daburon, Y. Tricaud & D. Bourhoven

  2. Département de Physiologie de la Nutrition, Institut National de la Recherche Agronomique, France

    P. A. Villiers

  3. Faculté de Medecine de PARIS XII, F-94000, Creteil

    P. L. Fagniez (Chef de Travaux)

  4. Faculté de Medecine de PARIS VII, X. Bichat, F-92110, Clichy, France

    J. M. Hay (Professeur Agrégé)

Authors
  1. F. Daburon
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  2. P. A. Villiers
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  3. P. L. Fagniez
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  4. J. M. Hay
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  5. Y. Tricaud
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  6. D. Bourhoven
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Daburon, F., Villiers, P.A., Fagniez, P.L. et al. Research on the therapeutics of intense abdominal irradiations in pigs. Radiat Environ Biophys 17, 67–83 (1979). https://doi.org/10.1007/BF01323121

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  • DOI: https://doi.org/10.1007/BF01323121

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