Summary
Exposure to toxins in the environment and due to personal habits, e. g., tobacco smoking, may increase the rate of spontaneous sister chromatid exchange (SCE). The SCE in lymphocytes from a group of 31 patients with multiple epidermal cancer, who in the past had been exposed to various skin carcinogens, as a whole exceeded that of a control group — matched by sex, age, and smoking habits — but the difference was not statistically significant (p=0.08). The individual SCE in these patients was also statistically independent of the nature of the carcinogenic exposure. We were unable to detect correlations between the SCE and UVC-radiation induced DNA synthesis, UVC-radiation tolerance, or rate of X-ray damage repair. This suggests that the molecular mechanisms involved in SCE induction and in repair of radiation damage are basically independent.
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Frentz, G., Wulf, H.C., Munch-Petersen, B. et al. Normal sister chromatid exchange in lymphocytes from patients with multiple epidermal cancer?. Arch Dermatol Res 279, 180–183 (1987). https://doi.org/10.1007/BF00413254
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DOI: https://doi.org/10.1007/BF00413254