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Tetanus intoxication causes an increment of serotonin in the central nervous system

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Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform thoughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected.

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References

  1. Wellhoner, H. H., Rev. Physiol. Biochem. Pharmac.93 (1982) 1.

    CAS  Google Scholar 

  2. Mellanby, J., and Green, J., Neuroscience6 (1981) 281.

    Article  CAS  PubMed  Google Scholar 

  3. Bizzinini, B., Microb. Rev.2 (1979) 224.

    Article  Google Scholar 

  4. Kryhzanovsky, G. N., in: Tetanus, Important New Concepts, pp. 109–182. Ed. R. Veronesi. Excepta Medica, Amsterdam 1981.

    Google Scholar 

  5. Helting, T. B., Zwiler, O., and Weigandt, H., J. biol. Chem.252 (1977) 194.

    Article  CAS  PubMed  Google Scholar 

  6. Craven, C. J., and Dawson, D. J., Biochim. biophys. Acta317 (1973) 277.

    Article  CAS  PubMed  Google Scholar 

  7. van Heyningen, S., Pharmac. Ther.11 (1980) 141.

    Article  Google Scholar 

  8. Dimpfel, W., TINS, April (1980) 80.

  9. Schwab, M., Agid, Y., Glowinski, J., and Thoenen, H., Brain Res.126 (1977) 221.

    Article  Google Scholar 

  10. Osborne, R. H., Bradford, H. F., and Jones, D. G., J. Neurochem.21 (1973) 407.

    Article  CAS  PubMed  Google Scholar 

  11. Curtis, D. R., and De Groat, W. C., Brain Res.10 (1968) 203.

    Article  Google Scholar 

  12. Curtis, D. R., Felix, D., Game, C. J. A., and McCulloch, R. M., Brain Res.51 (1973) 358.

    Article  CAS  PubMed  Google Scholar 

  13. Collingridge, G. L., Collins, G. G. S., Davies, J., James, T. A., Neal, M. J., and Tongroach, P., J. Neurochem.34 (1980) 540.

    Article  CAS  PubMed  Google Scholar 

  14. Choudhury, R. P., Mandal, S., and Narayanaswami, A., Indian J. med. Res.68 (1978) 21.

    CAS  PubMed  Google Scholar 

  15. Schwab, M. E., and Thoenen, H., Brain Res.105 (1976) 213.

    Article  CAS  PubMed  Google Scholar 

  16. Bigalke, H., Heller, I., Bizzini, B., and Habermann, E., Naunyn-Schmiedebergs Arch. Pharmak.316 (1981) 244.

    Article  CAS  Google Scholar 

  17. Anton, A. H., and Sayre, D. F., J. Pharmac. expl Ther.153 (1966) 15.

    CAS  Google Scholar 

  18. Curzon, G., and Green, R. A., Br. J. Pharmac.39 (1970) 653.

    Article  CAS  Google Scholar 

  19. Maikel, R. P., Cox, R. H., Saillant, J., and Miller, F. R., Int. J. Neuropharmac.7 (1968) 275.

    Article  Google Scholar 

  20. Fisher, C. A., and Aprison, M. H., Analyt. Biochem.46 (1972) 67.

    Article  Google Scholar 

  21. Escande, C., Bousquet, B., and Dreus, C., Ann. Biol. Chem.35 (1977) 387.

    CAS  Google Scholar 

  22. Davis, J. N., and Carlsson, A., J. Neurochem.21 (1973) 783.

    Article  CAS  PubMed  Google Scholar 

  23. Grahame-Smith, D. G., J. Neurochem.18 (1970) 1053.

    Article  Google Scholar 

  24. Fernstrom, J. D., Physiol. Rev.63 (1983) 484.

    Article  CAS  PubMed  Google Scholar 

  25. Sheard, M. H., and Aghajanian, Q. K., J. Pharmac. expl Ther.163 (1968) 425.

    CAS  Google Scholar 

  26. Shields, P. J., and Eccleston, D., J. Neurochem.19 (1972) 265.

    Article  CAS  PubMed  Google Scholar 

  27. Grahame-Smith, D. G., J. Neurochem.18 (1971) 1053.

    Article  CAS  PubMed  Google Scholar 

  28. Lin, R. C., Ngai, S. H., and Costa, E., Science166 (1969) 237.

    Article  CAS  PubMed  Google Scholar 

  29. Schubert, J., Nyback, H., and Sedvall, G., Eur. J. Pharmac.10 (1970) 215.

    Article  CAS  Google Scholar 

  30. Anden, N. E., Corrodi, H., and Fuxe, K., J. Pharmac. expl. Ther.179 (1971) 236.

    CAS  Google Scholar 

  31. Hamon, M., Bourgoin, S., Artaud, F., and Glowinski, J., J. Neurochem.33 (1979) 1031.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Autonoma de Barcelona, Bellaterra, Barcelona, Spain

    J. Aguilera, J. Heredero & F. Gonzalez Sastre

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  1. J. Aguilera
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  2. J. Heredero
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  3. F. Gonzalez Sastre
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Aguilera, J., Heredero, J. & Gonzalez Sastre, F. Tetanus intoxication causes an increment of serotonin in the central nervous system. Experientia 43, 410–412 (1987). https://doi.org/10.1007/BF01940431

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