Skip to main content
SpringerLink
Log in

Mitochondrial activity: A possible determinant of anoxic injury in renal medulla

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

In brain1, heart2 and kidney3, cell work in the absence of oxygen has been thought to precipitate anoxic damage by increasing the rate of depletion of cellular energy stores. In the medullary thick ascending limb of isolated perfused rat kidneys, however, reduction of ATP synthesis by a variety of mitochondrial or metabolic inhibitors caused ATP depletion comparable to that produced by oxygen deprivation but did not reproduce the lesions of anoxia. In these cells, unrestrained mitochondrial activity may be an important source of anoxic injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Rothman, S.M., Science220 (1983) 536.

    Article  CAS  PubMed  Google Scholar 

  2. Cheung, J.Y., Leaf, A., and Bonventre, J.V., Am. J. Physiol.246 (1984) C323.

    Article  CAS  PubMed  Google Scholar 

  3. Brezis, M., Rosen, S., Silva, P., Spokes, K., and Epstein, F.H., Science224 (1984) 66.

    Article  CAS  PubMed  Google Scholar 

  4. Chaudry, I.H., Am. J. Physiol.245 (1983) R117.

    CAS  PubMed  Google Scholar 

  5. Brezis, M., Rosen, S., Silva, P., and Epstein, F.H., J. clin. Invest.73 (1984) 182.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Brezis, M., Rosen, S., Silva, P., and Epstein, F.H., Kidney Int.26 (1984) 375.

    Article  CAS  PubMed  Google Scholar 

  7. Brezis, M., Rosen, S., Silva, P., and Epstein, F.H., Kidney Int.25 (1984) 65.

    Article  CAS  PubMed  Google Scholar 

  8. Gullans, S.R., Brazy, P.C., Soltoff, S.P., Dennis, V.W., and Mandel, L.J., Am. J. Physiol.243 (1982) F133.

    Article  CAS  PubMed  Google Scholar 

  9. Lehninger, A.L., Principals of Biochemistry, pp. 442/465. Worth Publishers, New York 1982.

    Google Scholar 

  10. Kondo, T., and Beutler, E.J., Lab. clin. Med.94 (1979) 617.

    CAS  Google Scholar 

  11. Brezis, M., Rosen, S., Spokes, K., Silva, P., and Epstein, F.H., Am. J. Path.116 (1984) 327.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Lamprecht, W., and Trautschold, I., in:Methods of Enzymatic Analysis. Ed. H.U. Bergmeyer, vol. 4, p. 2101. Academic Press, New York 1974.

    Google Scholar 

  13. Brezis, M., Rosen, S., Shanley, P., Spokes, K., Silva, P., and Epstein, F.H., Clin. Res.33 (1985) 479A.

    Google Scholar 

  14. Brezis, M., Rosen, S., Shanley, P., Silva, P., and Epstein, F.H., Proceedings of the IXth International Congress of Nephrology, 321A (1984).

  15. Hochachka, P.W., and Dunn, J.F., Prog. clin. biol. Res.136 (1983) 297.

    CAS  PubMed  Google Scholar 

  16. Farber, J.L., Lab. Invest.47 (1982) 114.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel

    M. Brezis

  2. The Charles A. Dana Research Institute, Boston, Massachusetts, USA

    S. Rosen, P. Silva, K. Spokes & F. H. Epstein

  3. the Harvard-Thorndike Laboratory of Beth Israel Hospital, Departments of Medicine and Pathology, Harvard Medical School and Beth Israel Hospital, Boston, Massachusetts, USA

    S. Rosen, P. Silva, K. Spokes & F. H. Epstein

Authors
  1. M. Brezis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Rosen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Spokes
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. H. Epstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brezis, M., Rosen, S., Silva, P. et al. Mitochondrial activity: A possible determinant of anoxic injury in renal medulla. Experientia 42, 570–572 (1986). https://doi.org/10.1007/BF01946708

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01946708

Key words

Search

Navigation