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Evidence for the lack of involvement of free radicals in adriamycin-induced histamine release from rat peritoneal cells

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Abstract

The antineoplastic drug adriamycin, at a concentration of 100 μg/ml, caused a significant histamine release from rat peritoneal mast cells. This exocytotic process was unaffected by pretreatment with various concentrations of catalase, superoxide-dismutase,d-mannitol, alpha-tocopherol and reduced glutathione. Only very high concentrations of n-acetylcysteine significantly limited this release; this substance was also active in limiting histamine secretion induced by a classic mast cell secretagogue, compound 48/80.

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References

  1. D. V. Unverferth, R. D. Magorien, C. V. Leier and S. P. Balcerzak,Doxorubicin cardiotoxicity, Cancer Treat. Rev.9, 149–164 (1982).

    PubMed  Google Scholar 

  2. M. R. Bristow, W. S. Sageman, R. H. Scott, M. E. Billingham, R. E. Bowden, R. S. Kernoff, G. H. Snidow and J. R. Daniels,Acute and chronic cardiovascular effects of doxorubicin in the dog: the cardiovascular pharmacology of drug-induced histamine release, J. Cardiovasc. Pharmacol.2, 487–515 (1980).

    PubMed  Google Scholar 

  3. M. R. Bristow, N. E. Kantrowitz, W. D. Harrison, W. A. Minobe, W. S. Sageman and M. E. Billingham,Mediation of subacute anthracycline cardiotoxicity in rabbits by cardiac histamine release, J. Cardiovasc. Pharmacol.5, 913–919 (1983).

    PubMed  Google Scholar 

  4. F. Bartoli Klugmann, G. Decorti, L. Candussio, V. Grill, F. Mallardi and L. Baldini,Inhibitors of adriamycin-induced histamine release ‘in vitro” limit adriamycin cardiotoxicity “in vivo”, Br. J. Cancer54, 743–748 (1986).

    PubMed  Google Scholar 

  5. C. E. Myers, W. P. McGuire, R. H. Liss, I. Ifrim, K. Grotzinger and R. C. Young,Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response, Science (Wash. D.C)197, 165–167 (1977).

    Google Scholar 

  6. J. H. Doroshow, G. Y. Locker, I. Ifrim and C. E. Myers,Prevention of doxorubicin cardiac toxicity in the mouse by n-acetylcysteine, J. clin. Invest.68, 1053–1064 (1983).

    Google Scholar 

  7. G. Decorti, F. Bartoli Klugmann, L. Candussio and L. Baldini,Characterization of histamine secretion induced by anthracyclines in rat peritoneal mast cells, Biochem. Pharmacol.35, 1939–1942 (1986).

    Article  PubMed  Google Scholar 

  8. E. Masini, M. Lodovici, R. Fantozzi, R. Brunelleschi, A. Conti and P. F. Mannaioni,Histamine release by free radicals: paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase, Agents and Actions18, 85–88 (1986).

    Article  PubMed  Google Scholar 

  9. H. Ohmori, K. Komoriya, H. Azuma, S. Kurozumi and Y. Hashimoto,Xanthine oxidase-induced histamine release from isolated rat peritoneal mast cells: involvement of hydrogen peroxide, Biochem. Pharmacol.28, 333–334 (1979).

    Article  PubMed  Google Scholar 

  10. P. A. Shore, A. Burkhalter and V. H. Cohn,A method for the fluorometric assay of histamine in tissues, J. Pharmacol. Exp. Ther.127, 182–186 (1959).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, University of Trieste, Via Valerio no 32, 34100, Trieste, Italy

    L. Candussio M.D., F. Bartoli Klugmann, G. Decorti & L. Baldini

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  1. L. Candussio M.D.
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  2. F. Bartoli Klugmann
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  3. G. Decorti
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  4. L. Baldini
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Candussio, L., Bartoli Klugmann, F., Decorti, G. et al. Evidence for the lack of involvement of free radicals in adriamycin-induced histamine release from rat peritoneal cells. Agents and Actions 23, 201–203 (1988). https://doi.org/10.1007/BF02142540

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  • DOI: https://doi.org/10.1007/BF02142540

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