Abstract
Moore, Meyer and Hudson recently reported on a new analytical reagent, tetramethyldipicrylamine (3,3′, 5,5′-tetramethyl - 2,2′,4,4′,6,6′ - hexanitrodiphenylamine) and recommended it for further study in the analytical chemistry of the alkali metals1. A routine screening of this reagent by the National Cancer Institute, US National Institutes of Health, later showed its capacity to bring about a small but significant inhibition of tumour growth. A further check of its biological activity was then carried out, and is described here. The results indicate that this compound has antibacterial activity against Gram-positive organisms and several strains of sulphadiazine-resistant Neisseria meningitidis.
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Moore, C. E., Meyer, T. S., and Hudson, J. W., Talanta, 13, 171 (1966).
Frank, P. F., Wilcox, C., and Finland, M., J. Lab. Clin. Med., 35, 188 (1950).
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MEYER, T., MOORE, C. & FRANK, P. Tetramethyldipicrylamine—a New Antibacterial Agent. Nature 215, 312 (1967). https://doi.org/10.1038/215312a0
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DOI: https://doi.org/10.1038/215312a0
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