Abstract
PREVIOUS studies1,2 using the feline encéphale isolé of Bremer have shown differential effects of certain drugs on the thresholds for electrocortical activation and behavioural arousal from sleep produced by auditory stimulation. In order to confirm and extend these results further experiments were carried out in conscious, chronic cat preparations carrying permanently implanted cortical recording electrodes3. For recording purposes these animals were placed in a constant-environment chamber fitted with a one-way glass window. Auditory stimuli were presented from a loudspeaker fitted in a side wall of the chamber, and the threshold for arousal was taken as the intensity of stimulation necessary to bring about abrupt desynchronization of the electrocorticogram and behavioural arousal.
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References
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KEY, B., BRADLEY, P. Effect of Drugs on Conditioning and Habituation to Arousal Stimuli in Animals. Nature 182, 1517–1519 (1958). https://doi.org/10.1038/1821517a0
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DOI: https://doi.org/10.1038/1821517a0
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