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The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing

Bio/Technology volume 6, pages 943–947 (1988)Cite this article

Abstract

Non-radioactive oligonucleotide probes for specific alleles of the HLA-DQα and β-globin loci have been synthesized and applied to forensic analysis and prenatal diagnosis. The results obtained with biotin-labeled, enzyme-labeled, and 32P-labeled probes are compared in the individuality analysis of different autopsy samples and the diagnosis of two fetuses at risk for sickle-cell anemia.

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Authors and Affiliations

  1. Cetus Corporation, 1400 Fifty-Third Street, Emeryville, CA, 94608

    Teodorica L. Bugawan, Randall K. Saiki, Corey H. Levenson, Robert M. Watson & Henry A. Erlich

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  1. Teodorica L. Bugawan
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  2. Randall K. Saiki
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  3. Corey H. Levenson
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  4. Robert M. Watson
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  5. Henry A. Erlich
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Bugawan, T., Saiki, R., Levenson, C. et al. The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing. Nat Biotechnol 6, 943–947 (1988). https://doi.org/10.1038/nbt0888-943

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  • DOI: https://doi.org/10.1038/nbt0888-943

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