Summary
Two cases of Noca dia asteroides infection were encountered out of 55 kidney transplant patients at Chiba University Hospital. One patient developed an extrapleural abscess and the other had a pulmonary infiltration with chest wall abscess. The patients were successfully treated by surgical drainage of the chest wall abscesses and by oral administration of minocycline. No adverse effects caused by minocycline were observed during the therapy.
From 1900, when the first case of Nocardia infection was reported in Japan, there have been 60 cases reported in Japanese literature through 1973, including those we observed. This is the first report on nocardiosis in kidney transplant patients and on successful treatment of nocardiosis with minocycline in Japan.
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References
Abe, I. and Shimizu, K.: A case report of Nocardiosis,Acta Paediatr. Jap. 76: 607–613, 1972 (in Japanese).
Aoyama, T. and Miyamoto, S.: Uber die menschenpathogene Strepto-Thrix Mitt. a. d. med. Fakult. d. k. Univ. zur Tokio.
Bach, M.C. et al.: Susceptibility of Nocardia asteroides to 45 antimicrobial agents in vitro,Antimicrobial agents and chemotherapy, 3: 1, 1973.
Bach, M. C. et al.: Pulmonary Nocardiosis: Therapy with minocycline and with erythromycin plus ampicillin,JAMA 224: 1378–1381, 1973.
Bach, M.C. et al.: Influence of rejection therapy on fungal and Nocardial infections in renal-transplant recipients,Lancet 1: 180–184, 1973.
Carlson, E.T. et al.: Nocardiosis and pulmonary alveolar proteinosis,Ann. Intern. Med. 60: 275–281, 1964.
Emmons, C.W. et al.: p. 94 in Medical Mycology, Lea und Febiger, Philadelphia, 1970.
Eppinger, H.L.: Uber eine neue Pathologene Caladothrix und eine durch sie hervorgerufense Pseudotuberculose,Beitr. x. path. Anat. u. all. Path. 9: 287–328, 1891.
Frazier, A.R. et al.: Nocardiosis, A review of 25 cases occurring during 24 months,Mayo Clin. Proc. 50: 657–663, 1975.
Fukushiro, R. et al.: Some observations on nocardiosis,Nishinihon J. Derm. 31: 205–236, 1969 (in Japanese).
Gallis, H.A. et al.: Fungal infection following renal transplantation,Arch. Intern. Med. 135: 1163–1172, 1975.
Goodman, J.S. and Koening, M.G.: Nocardia infections in General hospital,Ann. N.Y. Acad. Sci. 174: 552–567, 1970.
Gordon, R.E. and Mihm, J.M.: Identification Nocardia cavie,Ann. N. Y. Acad. Sci. 98: 628–636, 1962.
Hill, R.B. et al.: Death after transplantation,Am. J. Med. 42: 327–334, 1967.
Hitomi, Y. et al.:Japan J. Med. Mycol. 11: 205, 1970 (case report in Japanese).
Hosomi, Y. et al.:Toden IHO 2: 125–137, 1972 (case report in Japanese)
Ikada, J. and Fujiwara, T.: Nocardiosis,Jap. J. Clin. Dermat. 25: 595–599, 1971. (in Japanese with English summary).
Lerner, P.I. and Baum G.L.: Antimicrobial susceptibility of Nocardia species,Antimicro. Ag. Chemothera, 4: 85–93, 1973.
Matsumoto, K., et al.:J.J.A. Inf. D., 47: 373, 1973, (case report in Japanese).
Murray, J.F., Finegold, S.M., Froman, S., Will, D.W. et al.: The changing spectrum of Nocardiosis. A review and presentation of nine cases,Amer. Rev. Resp. Dis. 83: 315–330, 1961.
Naoe, S. et al.:Japan J. Med. Mycol. 13: 123, 1972 (case report in Japanese).
Nishimura M.:J.J.T.D. 6: 95, 1968 (case report in Japanese).
Nocard, E.: Note sur la maladie des beefs de la Gaudelope connue sous le nom fracin,Ann. Inst. Pasteur. 2: 293–302, 1888.
Palmer, D.L. et al.: Diagnostic and therapeutic considerations in Nocardia asteroides infection,Medicine 53: 391–401, 1971.
Pinklas, J. et al.: Pulmonary Nocardiosis complicating malignant lymphoma successfully treated with chemotherapy,Chest 63: 367–370, 1973.
Rifkind D. et al.: Systemic fungal infections complicating renal transplantation and immunosuppressive therapy,Am. J. Med. 43: 28–38, 1967.
Sato, R.:The Current Med. 18: 139–143, 1970 (case report in Japanese).
Shoji, A. et al.:Jap. J. Med. Mycel. 13: 122–123, 1972 (case report in Japanese).
Takizawa, K. et al.:Japan J. Med. Mycel. 13: 122, 1972.
Yamada, T.:Jap. Assoc. Thorac. Surg. 17: 1254–1255, 1969 (case report in Japanese).
Yamura, T.:J. Hiroshima Med. Ass. 21: 280–381, 1968 (case report in Japanese).
Yonaga, R. and Nadamitsu, Y.:J. Japan Soc. Intern. Med. 60: 345, 1971 (case report in Japanese).
Yokota, A. et al.:J. Japan Soc. Intern. Med. 60: 50–51, 1971 (case report in Japanese).
Yokoyama, T. et al.: Postoperative Complication in Cadaveric Renal Transplantation. pp. 186 (ed. by Y. Iwasaki), Igaku Shoin, Tokyo.
Young L.S. et al.: Nocardia asteroides infection complicating neoplastic disease.Am. J. Med. 50: 356–367, 1971.
Whitmore, D.D.: Nocardiosis in anemic patients given steroids,J. Clin. Pathol. 14: 259–263, 1961.
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Ochiai, T., Amemiya, H., Watanabe, K. et al. Successful treatment of nocardia asteroides infection with minocycline in kidney transplant patients. The Japanese Journal of Surgery 8, 138–144 (1978). https://doi.org/10.1007/BF02469369
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DOI: https://doi.org/10.1007/BF02469369