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Uptake kinetics of14C L-leucine and14C L- and14C D-methionine in rat brain and incorporation into protein

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Abstract

Because the amino acids11C L-leucine,11C L-methionine, and11C D-methionine are used for examinations of brain tumors with positron emission tomography (PET), the uptake of the corresponding14C substances and their incorporation into protein was studied in the rat brain. The uptake of all three substances from the plasma, across the bloodbrain barrier, and into the brain took place quite quickly; return to the plasma seemed negligible. Incorporation into protein took place much more slowly.

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Authors and Affiliations

  1. Department for Nuclear Medicine, School of Medicine, Hannover, West Germany

    Lutz Lauenstein, Geerd-Jürgen Meyer, Karl-Friedrich Sewing, Otmar Schober & Heinz Hundeshagen

  2. Department for Pharmacology, School of Medicine, Hannover, West Germany

    Karl-Friedrich Sewing

  3. Inst. f. Nuklearmedizin, Medizinische Hochschule Hannover, Postfach 610180, D-3000, Hannover 61, West Germany

    Geerd-Jürgen Meyer

Authors
  1. Lutz Lauenstein
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  2. Geerd-Jürgen Meyer
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  3. Karl-Friedrich Sewing
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  4. Otmar Schober
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  5. Heinz Hundeshagen
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Lauenstein, L., Meyer, GJ., Sewing, KF. et al. Uptake kinetics of14C L-leucine and14C L- and14C D-methionine in rat brain and incorporation into protein. Neurosurg. Rev. 10, 147–150 (1987). https://doi.org/10.1007/BF01741453

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  • DOI: https://doi.org/10.1007/BF01741453

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