Summary
We have determined the molecular characteristics of α-thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with α-and ζ-specific probes. We have found four types of defects in the α-thalassemia-2 genetic determinant: α3.7 type I; α4.2; αCS; and ααT. All HbH subjects carried the ——SEA genotype in the α-thalassemia-1 determinant. At least two different subtypes of ——SEA genotype were observed in this study.
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Peng, HW., Han, SH., Chow, TY. et al. The molecular basis of HbH disease in Taiwan. Hum Genet 78, 137–139 (1988). https://doi.org/10.1007/BF00278183
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DOI: https://doi.org/10.1007/BF00278183