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Analysis for possible linkage between the loci for the Waardenburg syndrome and various blood groups and serological traits

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Summary

Linkage was sought between the Waardenburg syndrome locus and the loci for various genetic markers segregating in a single family. Close linkage was shown to be unlikely with the loci for Rh, MN, Ag, ADA, HL-A, and Gm. Evidence obtained is consistent with the possibility of linkage with the locus for the AB0 blood group, but study of additional families will be required to provide a definite answer.

Zusammenfassung

In einer Familie wurde nach Genkopplung zwischen dem locus für das Waardenburg-Syndrom und verschiedenen genetischen Markern gefahndet. Für die loci für Rh, MN, Ag, ADA, HL-A und Gm wurde enge Kopplung als unwahrscheinlich erwiesen. Dagegen lassen die Daten die Annahme einer Kopplung mit dem AB0-locus zu. Für eine endgültige Entscheidung müßten zusätzliche Familien untersucht werden.

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Author notes

  1. Joe Leigh Simpson

    Present address: Department Obstetrics and Gynecology, Brooke Army Medical Center, 78234, San Antonio, Texas, USA

Authors and Affiliations

  1. New York Blood Center, Cornell University Medical College, New York City

    Joe Leigh Simpson, Catherine T. Falk, Gilda Morillo-Cucci, Fred H. Allen Jr. & James German

Authors
  1. Joe Leigh Simpson
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  2. Catherine T. Falk
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  3. Gilda Morillo-Cucci
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  4. Fred H. Allen Jr.
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  5. James German
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Additional information

Research supported by grants No. HD 04134, HL 09011, and HL 08630 from the National Institutes of Health.

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Simpson, J.L., Falk, C.T., Morillo-Cucci, G. et al. Analysis for possible linkage between the loci for the Waardenburg syndrome and various blood groups and serological traits. Humangenetik 23, 45–50 (1974). https://doi.org/10.1007/BF00295681

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  • DOI: https://doi.org/10.1007/BF00295681

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