Summary
Vibrio succinogenes produces an asparaginase that does not hydrolyze glutamine, is not immunosuppressive, and has antitumor activity. Fermentor cultures initiated by small inocula exhibit a pattern of increasing enzyme activity consistent with induction during exponential phase. Semi-continuous cultures permit the harvesting of fully induced cells.
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Covey, J., Greenstein, T. & Kafkewitz, D. Asparaginase synthesis by semi-continuous fermentor cultures of Vibrio succinogenes . Biotechnol Lett 3, 269–274 (1981). https://doi.org/10.1007/BF00127393
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DOI: https://doi.org/10.1007/BF00127393