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Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane

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Abstract

Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.

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Authors and Affiliations

  1. Department of Food and Nutrition Science, Gifu City Women's College, 502, Gifu, Japan

    T. Aoki

  2. Department of Physiology, Nagoya City University Medical School, Mizuho-ku, 467, Nagoya, Japan

    K. Nihonyanagi & T. Oba

Authors
  1. T. Aoki
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  2. K. Nihonyanagi
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  3. T. Oba
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Aoki, T., Nihonyanagi, K. & Oba, T. Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane. Experientia 49, 792–794 (1993). https://doi.org/10.1007/BF01923550

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  • DOI: https://doi.org/10.1007/BF01923550

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