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Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man

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Summary

Human α-atrial natriuretic peptide (h-αANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-αANP also occurs in subjects receiving indomethacin. Therefore, h-αANP antagonises effects of antidiuretic hormone on distal tubular V2-receptors in man, probably without involving prostaglandins.

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Author notes

  1. J. Brown

    Present address: The Physiological Laboratory, Downing Site, Downing Street, CB2 3EG, Cambridge

Authors and Affiliations

  1. Royal Postgraduate Medical School, Du Cane Road, W12, London, England

    J. Brown, G. Valdes & C. T. Dollery

  2. Department of Physiology, Middlesex Hospital Medical School, Cleveland Street, W1, London, England

    M. L. Forsling

  3. Cobbold Laboratories, Middlesex Hospital, Mortimer Street, W1, London, England

    J. D. H. Slater

Authors
  1. J. Brown
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  2. M. L. Forsling
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  3. G. Valdes
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  4. J. D. H. Slater
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  5. C. T. Dollery
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Brown, J., Forsling, M.L., Valdes, G. et al. Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man. Experientia 44, 513–516 (1988). https://doi.org/10.1007/BF01958933

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  • DOI: https://doi.org/10.1007/BF01958933

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