Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Comparative Study of MK-0787/MK-0791 and Piperacillin in Respiratory Tract Infections
Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Hiroshi KAWANE, Yoshihito NIKI, Masayoshi KAWANISHI, Chikara NAKAHAMA, Jiro HINO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kazuo TAKEBE, Yoshihiro KUMASAKA, Teruo NAKAMURA, Tsukasa YOSHIDA, Masayuki YOSHIZAWA, Kazuo MIZUKOSHI, Shiroh IDA, Tamotus TAKISHIMA, Seiichi AONUMA, Akira WATANABE, Kotaro OIZUMI, Kiyoshi KONNO, Tsugushi ITOH, Izumi HAYASHI, Masaaki ARAKAWA, Koichi WADA, Ryohji YOSHIDA, Ariyoshi KONDOH, Akio HOSHINO, Koichi HIRONO, Yukio NOZAWA, Haruo TERADA, Ryozoh ASANO, Masanori NARITA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiaki KAMEYAMA, Yoshiyuki UCHIDA, Masataka KATSU, Toshio FUKUI, Hajime YAMAGATA, Mieko KAWAI, Reiko SAITO, Minoru SATO, Takashi YOKOSE, Takeshi KAWAI, Akio ONAKA, Atsushi AJISAWA, Takeshi KAMO, Fuyuhiko HIGASHI, Masahiko NAKAMURA, Kazumi ARIKAWA, Keiichi YAMAGAMI, Makoto TAKANO, Sozo NUMASA, Yuzo FUNATSU, Mitsuo KITAHARA, Yukinori TAKAHASHI, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDOH, Toshinobu SATOH, Makoto DOI, Keimei MASHIMO, Tetsuro UKAI, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Motokazu TANAKA, Hajime MORINARI, Syuichi OKUBO, Kazuo FUJIEDA, Toshio ITOH, Kihachiro SHIMIZU, Teppei KUMADA, Satoshi OOI, Kyoichi TOTSUKA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Masahiko YOSHIDA, Ippei FUJIMORI, Yoshio KOBAYASHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITOH, Shigeki ODAGIRI, Hideyuki HASEGAWA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Hideo TAKAHASHI, Tomiji MIURA, Fumio MATSUMOTO, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Naohiro YAMASHITA, Kiyoshi HOSHINO, Eiji SUGIYAMA, Yutaka MIZUSHIMA, Saburo YANO, Kaoru OYAMA, Hideki NISHIYAMA, Hitoshi NAKAI, Kazukiyo OIDA, Nobuaki IKEDA, Hiroyuki TSUJINO, Mitsuo HASE, Eiichi MATSUYAMA, Fumiyuki KUZE, Yuruko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiro UEDA, Hiroshi OKUBO, Fumio MIKI, Akihito MURATA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Michio YAMAKIDO, Masao KUWABARA, Toshiya NOMURA, Toyofumi MITSUYAMA, Horoyuki ARITA, Akimitsu KAMITSUNA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Yoshiyuki NIHO, Nobuaki SHIGEMATSU, Osamu KOHASHI, Kiyoshi NINOMIYA, Hitoshi NAGANO, Takahito HIROSE, Atsusi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Shigeru KOHNO, Yoshiteru SHIGENO, Toshiro ODA, Hirosuke OHTA, Takashige MIYAZAKI, Toshiyuki OYE, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Harumi SISIDO, Yoshio UZUKA, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yoshinobu KURODA, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yuei IRABU, Minoru HIGA, Hiroaki NAKAMURA
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Keywords: MK-0787/MK-0791, Piperacillin, Respiratory tract infections, Comparative study
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1986 Volume 60 Issue 4 Pages 345-377

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Abstract

The clinical efficacy and safety of MK-0787/MK-0791 were compared with piperacillin (PIPC) in respiratory tract infections by a well controlled study. Drugs were administered by intravenous drip infusion twice a day for 14 days, at a daily of 1 g/1 g of MK-0787/MK-0791 or 4 g of PIPC.
The following results were obtained.
1. Out of 367 patients (183 administered MK-0787/MK-0791, 184 PIPC) included in this trial, the clinical efficacy of 301 patients (155 received MK-0787/MK-0791, 146 PIPC) was evaluated by the committee members.
2. The clinical efficacy rates in all cases evaluated by the committee members were 80.0% in MK-0787/MK-0791 and 71.7% in PIPC, respectively, and no significant difference was observed between the two drugs. Wheras, the clinical efficacy rates evaluated by the attending physicians were 82.0% in MK-07871/MK-0791 and 72.0% in PIPC, and significant difference was observed between the two drugs.
3. No significant difference was observed between the clinical efficacy of the two drugs evaluated by the committee members in patients with pneumonia or pulmonary suppuration. But in patients with chronic respiratory tract infections, the clinical efficacy rates were 83.5% in MK-0787/MK-0791 and 63.0% in PIPC, respectively, therefore MK-0787/MK-0791 was significantly superior to PIPC. The clinical efficacy evaluated by both the attending physicians and the committee members in those patients were observed to be similar.
4. The clinical and bacteriological efficacy against causative organisms in all cases were observed to have no significant difference between the two drugs, but MK-0787/MK-0791 was significantly superior to PIPC in single infections by P. aeruginosa.
5. No significant difference was observed between the two drugs in regard to side effects or abnormality in laboratory findings.
6. The usefulness of MK-0787/MK-0791 was superior to PIPC in all cases and in patients with chronic respiratory tract infections judged by committee members, and in patients with chronic respiratory tract infections judged by attending physicians.
From these results it was concluded that MK-0787/MK-0791 is an extremely useful drug in the treatment of respiratory tract infections.

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