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PS5 - 30. Deciphering glycosphingolipid metabolism in sorted adipose tissue macrophages from lean and obese mice.

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Nederlands Tijdschrift voor Diabetologie Aims and scope

Abstract

Glycosphingolipids (GSL) essentially contribute to the development of insulin resistance (IR) in adipose tissue. On one hand GSL such as the ganglioside GM3 have been shown to cause insulin resistance (IR) in adipocytes, on the other hand macrophages have to buffer adipose lipid spillage causing a foamy cell appearance.

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Authors and Affiliations

  1. Departments of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Tanit L. Gabriel, Roelof Ottenhof, Cindy van Roomen, Johanes M.F.G. Aerts & Marco van Eijk

  2. Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Berend Hooibrink

Authors
  1. Tanit L. Gabriel
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  2. Roelof Ottenhof
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  3. Cindy van Roomen
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  4. Berend Hooibrink
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  5. Johanes M.F.G. Aerts
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  6. Marco van Eijk
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Corresponding author

Correspondence to Tanit L. Gabriel.

Additional information

Departments of 1 Medical Biochemistry and 2 Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. E-mail: t.l.gabriel@amc.uva.nl

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Gabriel, T., Ottenhof, R., van Roomen, C. et al. PS5 - 30. Deciphering glycosphingolipid metabolism in sorted adipose tissue macrophages from lean and obese mice.. NED. TIJDSCHR. DIABET. 10, 118 (2012). https://doi.org/10.1007/s12467-012-0064-5

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  • DOI: https://doi.org/10.1007/s12467-012-0064-5

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