Skip to main content

Advertisement

SpringerLink
Log in

Electro-oculographic findings after 360° retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate potential electro-oculographic changes after 360° retinotomy and macular translocation for subfoveal choroidal neovascularisation in patients with age-related macular degeneration (AMD) in a randomised comparative (self-controlled) trial.

Methods

A consecutive series of 30 patients suffering from subfoveal choroidal neovascularisation secondary to age-related macular degeneration underwent 360° retinotomy and macular translocation. The EOG served as the main parameter of the study and was recorded 1 day prior to the translocation surgery and no earlier than 21 days after the silicone oil removal.

Results

Postoperatively, a statistically significant decrease in mean dark trough by 64% was found for treated eyes (P<0.001). The mean dark trough of the fellow eye remained stable after surgery (P=0.33). The postoperative difference between the treated und untreated eyes proved to be statistically significant (P<0.001). The Arden ratio remained stable in the treated and untreated eyes with mean values of 204% (P=0.81) and 213% (P=0.18), respectively. A significant correlation between the reduction of the dark trough and the visual acuity at the 1-year follow-up was found.

Conclusions

A persistent decrease in the corneofundal potential is associated with 360° retinotomy and macular translocation for exudative AMD. This indicates a substantial postoperative malfunction of retinal pigment epithelial cells and an impaired photoreceptor regeneration. The impeded recovery of the RPE-photoreceptor complex can be interpreted as the result of the surgical trauma on the basis of prediseased RPE. A severe postoperative decrease in dark trough forecasts an incomplete recovery of visual acuity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aisenbrey S, Lafaut BA, Szurman P, Grisanti S, Lüke C et al. (2002) Macular translocation with 360° retinotomy for exudative age-related macular degeneration. Arch Ophthalmol 120:451–459

    PubMed  Google Scholar 

  2. Alexandridis E, Anagnostopoulos C, Lauer HJ (1975) Netzhautfunktion nach operativer Behandlung der Amotio. II. Amotio mit Makulabeteiligung. Bericht zur 74. Zusammenkunft der DOG. München: Bergmann: 98–104

  3. Arden GB, Barrada A, Kelsey JH (1962) New clinical test of retinal function based upon the standing potential of the eye. Br J Ophthalmol 46:449–467

    Google Scholar 

  4. Armaly MF. Ocular tolerance to silicones (1962) Replacement of aqueous and vitreous by silicone fluids. Arch Ophthalmol 68:390

    CAS  Google Scholar 

  5. Bressler NM, Bressler SB, Gragoudas ES, et al. (1987) Clinical characteristics of choroidal neovascular membranes. Arch Ophthalmol 105:209–213

    CAS  Google Scholar 

  6. Constable I. Superviscous silicone oil (1982) Aust J Ophthalmol 10:5-11

    Google Scholar 

  7. De Juan EJ, Loewenstein A, Bressler NM, et al. (1998) Translocation of the retina for management of subfoveal choroidal neovascularization, II: a preliminary report in humans. Am J Ophthalmol 125:635–646

    Article  PubMed  Google Scholar 

  8. Elenius V, Aantaa E. (1973) Light-induced increase in amplitude of electro-oculogram. Evoked with blue and red lights in totally color-blind and normal humans. Arch Ophthalmol 90:60–63

    CAS  PubMed  Google Scholar 

  9. Ferris FL, Kassof A, Bresnick GH, et al. (1982) New visual acuity charts for clinical research. Am J Ophthalmol 94:91–96

    PubMed  Google Scholar 

  10. Fisher SK, Anderson DH (1998) Cellular responses of the retinal pigment epithelium to retinal detachment and reattachment. In: Marmor MF, Wolfensberger TJ (eds) The Retinal Pigment Epithelium. Oxford University Press, New York, pp 406–419

  11. Foulds WS, Ikeda H (1966) The effects of detachment of retina on the induced and resting ocular potentials in the rabbit. Invest Ophthalmol Vis Sci 5:93–108

    Google Scholar 

  12. Francois J, De Rouck A, Cambie E, Castanheira-Dinis A (1978) Electrophysiological studies before and after argon-laser photocoagulation in diabetic retinopathy. Ophthalmologica 176:133–144

    Google Scholar 

  13. Frumar KD, Gregor ZJ, Carter RM, et al. (1985) Electroretinographic changes after vitrectomy and intraocular tamponade. Retina 5(1): 16–21

    CAS  PubMed  Google Scholar 

  14. Fujikado T, Ohji M, Saito Y, et al. (1998) Visual function after foveal translocation with scleral shortening in patients with myopic neovascular maculopathy. Am J Ophthalmol 125:647–656

    Article  PubMed  Google Scholar 

  15. Gass JDM (1973) Drusen and disciform macular detachment and degeneration. Arch Ophthalmol 90:206–217

    CAS  PubMed  Google Scholar 

  16. Imai K, Loewenstein A, de Juan EJ (1998) Translocation of the retina for management of subfoveal choroidal neovascularization, I: experimental studies in the rabbit eye. Am J Ophthalmol 125:627–634

    Article  CAS  PubMed  Google Scholar 

  17. Krastel H, Alexandridis E (1980) Recovery from macular photostress and slow retinal potentials in cured retinal detachment. Ophthalmologica 181:47–52

    CAS  PubMed  Google Scholar 

  18. Lee P, Donovan RH, Mukai N (1969) Intravitreous injection of silicone: an experimental study. I. Clinical picture and histology of the eye. Ann Ophthalmol 1:15

    Google Scholar 

  19. Leibowitz HM, Maunder LR, Milton RC (1980) The Framingham Eye Study Monograph. Surv Ophthalmol 24:335–610

    CAS  PubMed  Google Scholar 

  20. Lewis GP, Fisher SK (2000) Müller cell outgrowth after retinal detachment: association with cone photoreceptors. Invest Ophthalmol Vis Sci 41(6): 1542–5

    CAS  PubMed  Google Scholar 

  21. Lindsey P, Finkelstein D, D`Anna S (1983) Experimental retinal relocation. Invest Ophthalmol Vis Sci 24(Suppl. 3): 242

    Google Scholar 

  22. Lobes LA (1978) The electro-oculogram in human retinal detachment. Br J Ophthalmol 62:223–226

    CAS  PubMed  Google Scholar 

  23. Lüke C, Aisenbrey S, Lüke M, Marzella G et al. (2001) Electrophysiological changes after 360° retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration. Br J Ophthalmol 85(8): 928–932

    Article  PubMed  Google Scholar 

  24. Machemer R, Steinhorst UH (1993) Retinal separation, retinotomy, and macular translocation, I: experimental studies in the rabbit eye. Graefes Arch Clin Exp Ophthalmol 231:629–634

    Google Scholar 

  25. Machemer R, Steinhorst UH (1993) Retinal separation, retinotomy, and macular relocation, II: a surgical approach for age-related macular degeneration? Graefes Arch Clin Exp Ophthalmol 231:635–641

    Google Scholar 

  26. Macular Photocoagulation Study Group (1991) Laser photocoagulation of subfoveal recurrent neovascular lesions in age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol 109:1232–1241

    Google Scholar 

  27. Macular Photocoagulation Study Group (1993) Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration: updated findings from two clinical trials. Arch Ophthalmol 111:1200–1209

    Google Scholar 

  28. Macular Photocoagulation Study Group (1994) Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol 112:480–488

    PubMed  Google Scholar 

  29. Marcus M, Merin S, Wolf M, Feinsod M. (1983) Electrophysiologic tests in assessment of senile macular degeneration. Ann Ophthalmol 15:235–238

    CAS  PubMed  Google Scholar 

  30. Marmor MF (1998) Standardization notice: EOG standard reapproved. Electro-oculogram. Doc Ophthalmol 95(1): 91–92

    Article  CAS  PubMed  Google Scholar 

  31. Marmor MF, Lurie M (1979) Light-induced electrical responses of the retinal pigment epithelium. In: Zinn KM, Marmor MF (eds) The Retinal Pigment Epithelium. Harvard University Press, Cambridge, pp 226–244

  32. Marmor MF, Zrenner E (1993) Standard for clinical electro-oculography. International Society for Clinical Electrophysiology of Vision. Arch Ophthalmol 111(5): 601–604

    Google Scholar 

  33. Meredith TA, Lindsey DT, Edelhauser HF Goldman AI. (1985) Electroretinographic studies following vitrectomy and intraocular silicone oil injection. Br J Ophthalmol 69(4): 254–260

    CAS  PubMed  Google Scholar 

  34. Miller JW, Schmidt-Erfurth U, Sickenberg M, et al. (1999) Photodynamic therapy with verteporfin for choroidal neovascularisation caused by age-related macular degeneration. Arch Ophthalmol 117:1161–1173

    CAS  PubMed  Google Scholar 

  35. Momirov D, van Lith GHM, Zivojnovic R (1983) Electroretinogram and Electrooculogram of eyes with intravitreously injected silicone oil. Ophthalmologica 186:183–188

    CAS  PubMed  Google Scholar 

  36. Ninomiya Y, Lewis JM, Hasegawa T, et al. (1996) Retinotomy and foveal translocation for surgical management of subfoveal choroidal neovascular membranes. Am J Ophthalmol 122:613–621

    CAS  PubMed  Google Scholar 

  37. Ober RR, Blanks JC, Ogden TE (1983) Experimental retinal tolerance to liquid silicone. Retina 3:77–84

    CAS  PubMed  Google Scholar 

  38. Schmidt B (1970) Elektrooculographische Untersuchungen bei Ablatio retinae. Graefes Arch Clin Exp Ophthalmol 180:20–30

    CAS  Google Scholar 

  39. Treatment of Age-related Macular Degeneration With Photodynamic Therapy Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularisation in age-related macular degeneration with verteporfin. Arch Ophthalmol 117:1329–1345

    PubMed  Google Scholar 

  40. Walter P, Widder RA, Lüke C, et al. (1999) Electrophysiological abnormalities in age-related macular degeneration. Graefe`s Arch Clin Exp Ophthalmol 237:962–968

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center of Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924 , Cologne, Germany

    Christoph Lüke, Nils Alteheld, Sabine Aisenbrey, Matthias Lüke, Peter Walter & Bernd Kirchhof

  2. Department of Ophthalmology, University of Tübingen, Germany

    Karl Ulrich Bartz-Schmidt

Authors
  1. Christoph Lüke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nils Alteheld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sabine Aisenbrey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Matthias Lüke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Karl Ulrich Bartz-Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Peter Walter
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bernd Kirchhof
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christoph Lüke.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lüke, C., Alteheld, N., Aisenbrey, S. et al. Electro-oculographic findings after 360° retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 241, 710–715 (2003). https://doi.org/10.1007/s00417-003-0709-6

Download citation

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-003-0709-6

Keywords

Search

Navigation