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Substituted urea/thiourea derived from fluoxetine as potent appetite suppressants

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Abstract

A series of urea and thiourea analogues of fluoxetine (5–17) were synthesized and evaluated for their anorexigenic and antidepressant activities. The related conformationally restrained analogues (20–23) were also prepared for structure–activity relationship (SAR) studies. Many of these derivatives (5, 6, 8, 10, 12, 13, 16, and 23) exhibited significant anorexigenic activity and interestingly were devoid of antidepressant activity, thus emerging as a promising tool for further research work.

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Acknowledgements

Financial assistance from Council of Scientific and Industrial Research, New Delhi (SS and LS) and the University Grant Commission (NS) is gratefully acknowledged.

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Authors and Affiliations

  1. Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India

    Kalpana Bhandari, Nagarapu Srinivas, Lata Sharma & Shipra Srivastava

  2. Pharmacology Division, Central Drug Research Institute, Lucknow, 226001, India

    Amar Nath & Chandishwar Nath

Authors
  1. Kalpana Bhandari
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  2. Nagarapu Srinivas
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  3. Lata Sharma
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  4. Shipra Srivastava
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  5. Amar Nath
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  6. Chandishwar Nath
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Corresponding author

Correspondence to Kalpana Bhandari.

Additional information

C.D.R.I. communication No 7022

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Bhandari, K., Srinivas, N., Sharma, L. et al. Substituted urea/thiourea derived from fluoxetine as potent appetite suppressants. Med Chem Res 17, 103–113 (2008). https://doi.org/10.1007/s00044-007-9041-8

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  • DOI: https://doi.org/10.1007/s00044-007-9041-8

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