Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Clinical Efficacy of Fosfomycin in Combination with Sulbactam/Cefoperazone in the Treatment of Severe Infections Complicated to Blood Dyscrasia
Working Group of Kanto Combination Therapy for F0M+SBT/CPZ
Kiyoshi KITAMURA, Hisamaru HIRAI, Noriko HOSOYA, Masao SUGAI, Masamitu KARASAWA, Takuji NARUSE, Yasusada MIURA, Ken OHMINE, Syojiro TAKAGI, Kunitake HIRASHIMA, Masami BESSHO, Masataka FUKUDA, Nobutaka KAWAI, Kazuo DAN, Emi AN, Tetsuo HOSHINO, Kazuo OSHIMI, Masaaki NOGUCHI, Motoki EGASHIRA, Yasuo IKEDA, Masahiro KIZAKI, Keisuke TOYAMA, Keisuke MIYAZAWA, Masaya NAGASU, Yuka INATOMI, Yuzuru KURIYAMA, Osamu IWASE, Hideaki MIZOGUCHI, Shoko KOBAYASHI, Nobuyoshi TSURUOKA, Shigeru TOMOYASU, Tsuyoshi NAKAMAKI, Yoshihisa AKIMOTO, Tsunayuki KAKIMOTO, Yoshitomo MUTO, Junichi UEYAMA, Atsushi TOGAWA, Akiyoshi MIWA, Mari NAGAI, Akio URABE, Mitsue ENDO, Mayumi MORI, Ken KURAMOTO, Masayuki KIKUKAWA, Noriko NAKAMURA, Kenshi SUZUKI, Yasuyuki INOUE, Masakazu SAWANOBORI, Yasuaki NAKAGAWA, Kyozo ISHIKAWA, Koichi KAWANO, Masashi HOMORI, Yoshiro MURAI, Ryoko MIZUTANI, Kyoko NAKAMURA, Mitsuhiro OMINE, Hikaru FUJIWARA, Shyozo CHIBA, Akira HIRASAWA
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Keywords: hematological disorders, fosfomycin, sulbactam/cefoperazone, combination therapy
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1998 Volume 72 Issue 7 Pages 761-770

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Abstract

In the treatment of severe infections complicated to blood dyscrasia, the efficacy and usefulness of fosfomycin (FOM) in combination with sulbactam (SBT)/cefoperazone (CPZ) were compared between patients receiving FOM in the first followed by SBT/CPZ (Group A) and those receiving both drugs simultaneously (Group B). The following results were obtained.
1. The efficacy rate was 56.3% for Group A and 47.9% for Group B, with no significant difference.
2. The efficacy for patients suspected of the presence of septicemia, the efficacy rate was 57.9% for Group A and 54.3% for Group B, with no significant difference.
3. As for underlying disease, patients with acute myelogenous leukemia were most prevailing. In these patients, the efficacy rate was 57.1% for Group A and 27.3% for Group B, with no statistically significant difference. However, the efficacy rate tended to be higher in Group A.
4. The administration of antibiotics was effective to restore the neutrophil count to 501/μl or higher in 77.8% and 45.5% of the cases for Groups A and B, respectively, with significantly higher efficacy for Group A.
5. In the safety evaluation a total of 115 cases were included. Side effects and laboratory abnormalities were seen in 3 cases each, but none of them were serious in degree.
From these results, it was confirmed that the combination therapy consisting of administra-tion of FOM followed by SBT/CPZ with some interval is effective for severe inf ections complicated to blood dyscrasia.

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