Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Clinical Evaluation of Cefuzonam (CZON) for Bacterial Pneumonia and Lung Abscess Comparative Study with Cefotiam (CTM)
Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Masahiko YOSHIDA, Akira SAITO, Ichiro NAKAYAMA, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Hiroaki TANAKA, Tsukiko TOMIYAMA, Kenichi KIMURA, Kazuya KANNARI, Shiro KOSAKA, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Yutaka TOKUE, Reiko ONO, Yoshihiro HONDA, Satoshi SHOJI, Naoto KITAMURA, Izumi HAYASHI, Masaaki ARAKAWA, Masanaga TAKATO, Koichi WADA, Norio SUZUKI, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Hiroichi TANIMOTO, Koichiro NAKATA, Yoshitaka NAKAMORI, Tatsuo NAKATANI, Hiroshi NARUI, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Hiroyuki NUMATA, Kenichi TAKAHASHI, Izumi KOYAMA, Shunichi ISHII, Fumio MIKI, Rinzo SOEJIMA, Jiro HINO, Toshiharu MATSUSHIMA, Jun TANABE, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Tadao MORIMOTO, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Yasumasa DOUTSU, Toshiaki HAYASHI, Mitsuo KAKU, Shinichiro KANZAKI, Masao NAKATOMI, Kohta KOHNO, Takakazu KITANI, Hiroshi TOMITA, Osamu SAKITO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Atsushi TAKAHASHI, Masakazu TAKASUGI, Hironori MASAKI, Masaru NASU, Yoichiro GOTO, Hideaki SHIGENO, Jun GOTO, Takayoshi TASHIRO, Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Keizo YAMAGUCHI, Kazuyuki SUGAHARA, Chikako MOCHIDA, Mitsuyoshi NAKASHIMA
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Keywords: cefuzonam, cefotiam, bacterial pneumonia, lung abscess, comparative study
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1991 Volume 65 Issue 4 Pages 381-399

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Abstract

A double blind study was conducted to objectively evaluate the usefulness of Cefuzonam (CZON) in the treatment of bacterial pneumonia and lung abscess.
Cefotiam (CTM) was used as a control drug. Each drug was administered by intravenous dripinfusion at 1 g at a time, twice aily, for 14 days as a rule.
The results are as follows:
1. Enrolled in this study were 145 cases in total, comprising 72 of CZON group and 73 of CTM group. Of the total cases, 109 (53 of CZON group and 56 CTM group) were evaluated for clinicalefficacy by the evaluation committee. Exclusion rate and background of patients were not significantly different between the two groups.
2. Clinical effectiveness assessed by the committee showed the efficacy rates of 84.9%(45 cases out of 53) for the CZON group and 83.3%(47 cases out of 56) for the CTM group, with no significant difference between the two groups.
3. The bacteriological eradication rates were 89.5%(17 strains out of 19) for the CZON group and 78.3%(18 strains out of 23) for the CTM group, with no significant difference between the two groups.
5. Usefulness rates caluculated by the commitee were 79.2%(42 cases out of 53) for the CZON group and 76.8%(43 cases out of 56) for the CTM group. There was no significant difference between the two groups.
These results show that CZON is a useful drug in the treatment of bacterial pneumonia and lung abscess.

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