Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Comparative Study of Cefuzonam (CZON) with Cefmenoxime in Chronic Respiratory Tract Infections by Double Blind Method
Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, [in Japanese], Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, Masao NAKATOMI
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Keywords: Cefuzonam, Cefotiam Chronic respiratory infections Comparative study
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1986 Volume 60 Issue 8 Pages 865-884

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Abstract

A double blind comparative study was conducted to objectively evaluate the clinical efficacy and safety of Cefuzonam (CZON) in the treatment of chronic respiratory infections. Cefmenoxime (CMX) was used as a control drug. Each drug was administered by intravenous drip infusion 1g at a time, twice daily, for 14 days as a rule.
The results were as follows:
1. Treated in this study were 167 cases in total, 88 of CZON group and 79 of CMX group, but subjected for clinical evaluation by the evaluation committee were 147 cases, 77 of CZON group and 70 of CMX group, with 20 cases (11 of CZON group and 9 of CMX group) excluded from the committee's evaluation.
2. Clinical effectiveness assessed by the committee showed the efficacy rates of 81.8%(63 cases our of 77) for CZON group and 80.0%(56 cases out of 70) for CMX group, with no significant difference observed between the two drug groups. Also, there was no significant difference between the two groups in clinical efficacy evaluation by physicians in charge.
3. Classified by causal bacteria, clinical efficacy rates were 85.2% for CZON group and 78.6% for CMX group, and in single infection cases of gram-positive bacteria the effectiveness rates were 100% for CZON group and 75.0% for CMX group. In these two evaluations, CZON group showed higher efficacy percentages but no statistically significant difference was observed between the two drug groups. As for bacterial eradication rate, CZON group showed higher percentage but no significant difference was noted.
4. The incidence rate of abnormality in laboratory tests was lower for CZON than for CMX, but no significant difference was observed. Side effects incidence rates showed no significant difference between the two groups.
5. Usefulness rates by the evaluation of the committee were 77.9%(60 cases out of 77) for CZON group and 77.1%(54 cases out of 70) for CMX group, whereas evaluation by physicians in charge were 71.1%(54 cases out of 76) for CZON group and 82.6%(57 cases out of 69) for CMX group. In either evaluation, there was no significant difference observed between the two drug groups.
These results show that CZON is a useful drug in the treatment of chronic respiratory infections.

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© The Japansese Association for Infectious Diseases
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