Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
The Second Department of Internal Medicine, Hokkaido University School of Medicine and Related Institute
The Second Department of Internal Medicine, Hokkaido University School of Medicine and Related Institute
The Second Department of Internal Medicine, Hokkaido University School of Medicine and Related Institute
The Third Department of Internal Medicine, Hirosaki University School of Medicine
The Third Department of Internal Medicine, Hirosaki University School of Medicine
The Third Department of Internal Medicine, Hirosaki University School of Medicine
Department of Respiratory Disease, Iwate Prefectural Central Hospital
Department of Respiratory Disease, Iwate Prefectural Central Hospital
Department of Respiratory Disease, Iwate Prefectural Central Hospital
The First Department of Internal Medicine, Tohoku University School of Medicine
The First Department of Internal Medicine, Tohoku University School of Medicine
Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Pneumology, Takeda General Hospital
Department of Respiratory Disease, Iwaki Kyoritsu General Hospital
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
The Second Department of Internal Medicine, Niigata University School of Medicine
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Respiratory Disease, University of Tsukuba, School of Medicine and Related Institute
Department of Respiratory Disease, University of Tsukuba, School of Medicine and Related Institute
Department of Respiratory Disease, University of Tsukuba, School of Medicine and Related Institute
Department of Respiratory Disease, University of Tsukuba, School of Medicine and Related Institute
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Keioh University Hospital
Department of Internal Medicine, Keioh University Hospital
Department of Internal Medicine, Keioh University Hospital
Department of Internal Medicine, Keioh University Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Jikei University School of Medicine
The Second Department of Internal Medicine, Jikei University School of Medicine
The Second Department of Internal Medicine, Jikei University School of Medicine
The Second Department of Internal Medicine, Jikei University School of Medicine
Department of Chest Clinics, Toranomon Hospital
Department of Chest Clinics, Toranomon Hospital
Department of Chest Clinics, Toranomon Hospital
Department of Chest Clinics, Toranomon Hospital
Department of Chest Clinics, Toranomon Hospital
Department of Chest Clinics, Toranomon Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Respiratory Disease, Tokyo Teishin Hospital
Department of Respiratory Disease, Tokyo Teishin Hospital
Department of Respiratory Disease, Tokyo Teishin Hospital
Department of Respiratory Disease, Tokyo Teishin Hospital
Department of Respiratory Disease, Tokyo Teishin Hospital
Department of Internal Medicine, Tokyo Women's Medical college
Department of Internal Medicine, Tokyo Women's Medical college
Department of Internal Medicine, Tokyo Women's Medical college
Department of Internal Medicine, Tokyo Women's Medical college
Department of Internal Medicine, Juntendo University School of Medicine
Department of Internal Medicine, Juntendo University School of Medicine
Infections Disease Section, Tokyo Metropolitan Geriatric Hospital and Related Institute
Infections Disease Section, Tokyo Metropolitan Geriatric Hospital and Related Institute
Infections Disease Section, Tokyo Metropolitan Geriatric Hospital and Related Institute
The First Department of Internal Medicine, Kyorin University School of Medicine
The First Department of Internal Medicine, Kyorin University School of Medicine
The First Department of Internal Medicine, Kyorin University School of Medicine
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Yokohama Teishin Hospital
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
The First Department of Internal Medicine, Yokohama City University School of Medicine and Related Institute
Department of Internal Medicine, Kanagawa Prefectural Nursing and Hygienic School Hospital
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Institute
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Institute
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Institute
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Institute
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
The First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
The First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
The First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
The First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
The First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
Department of Internal Medicine, Toyama Prefectural Central Hospital
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Medicine, Chest Disease Research Institute, Kyoto University and Related Institute
The First Department of Internal Medicine, Kansai Medical University and Releated Institute
The First Department of Internal Medicine, Kansai Medical University and Releated Institute
The First Department of Internal Medicine, Kansai Medical University and Releated Institute
The First Department of Internal Medicine, Kansai Medical University and Releated Institute
The First Department of Internal Medicine, Kansai Medical University and Releated Institute
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Hiroshima University School of Medicine and Releated Institute
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
Research Institute for Disease of the chest, Faculty of Medicine, Kyushu University
Research Institute for Disease of the chest, Faculty of Medicine, Kyushu University
Research Institute for Disease of the chest, Faculty of Medicine, Kyushu University
Minami Fukuoka National Chest Hopsital
Minami Fukuoka National Chest Hopsital
Department of Internal Medicine, Ohmuta Byoin National Sanatorium
Department of Internal Medicine, Ohmuta Byoin National Sanatorium
Department of Internal Medicine, Ohmuta Byoin National Sanatorium
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Releated Institute
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The First Department of Internal Medicine, Kumamoto University School of Medicine
The First Department of Internal Medicine, Kumamoto University School of Medicine
The First Department of Internal Medicine, Kumamoto University School of Medicine
The First Department of Internal Medicine, Kumamoto University School of Medicine
The First Department of Internal Medicine, University of the Ryukyus School of Medicine
The First Department of Internal Medicine, University of the Ryukyus School of Medicine
The First Department of Internal Medicine, University of the Ryukyus School of Medicine
The First Department of Internal Medicine, University of the Ryukyus School of Medicine
Department of Internal Medicine, Okinawa Red Cross Hospital
Department of Internal Medicine, Okinawa Red Cross Hospital
1986 Volume 60 Issue 4 Pages 345-377
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The clinical efficacy and safety of MK-0787/MK-0791 were compared with piperacillin (PIPC) in respiratory tract infections by a well controlled study. Drugs were administered by intravenous drip infusion twice a day for 14 days, at a daily of 1 g/1 g of MK-0787/MK-0791 or 4 g of PIPC.
The following results were obtained.
1. Out of 367 patients (183 administered MK-0787/MK-0791, 184 PIPC) included in this trial, the clinical efficacy of 301 patients (155 received MK-0787/MK-0791, 146 PIPC) was evaluated by the committee members.
2. The clinical efficacy rates in all cases evaluated by the committee members were 80.0% in MK-0787/MK-0791 and 71.7% in PIPC, respectively, and no significant difference was observed between the two drugs. Wheras, the clinical efficacy rates evaluated by the attending physicians were 82.0% in MK-07871/MK-0791 and 72.0% in PIPC, and significant difference was observed between the two drugs.
3. No significant difference was observed between the clinical efficacy of the two drugs evaluated by the committee members in patients with pneumonia or pulmonary suppuration. But in patients with chronic respiratory tract infections, the clinical efficacy rates were 83.5% in MK-0787/MK-0791 and 63.0% in PIPC, respectively, therefore MK-0787/MK-0791 was significantly superior to PIPC. The clinical efficacy evaluated by both the attending physicians and the committee members in those patients were observed to be similar.
4. The clinical and bacteriological efficacy against causative organisms in all cases were observed to have no significant difference between the two drugs, but MK-0787/MK-0791 was significantly superior to PIPC in single infections by P. aeruginosa.
5. No significant difference was observed between the two drugs in regard to side effects or abnormality in laboratory findings.
6. The usefulness of MK-0787/MK-0791 was superior to PIPC in all cases and in patients with chronic respiratory tract infections judged by committee members, and in patients with chronic respiratory tract infections judged by attending physicians.
From these results it was concluded that MK-0787/MK-0791 is an extremely useful drug in the treatment of respiratory tract infections.