The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The Second Department of Internal Medicine, Hokkaido University , School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University , School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University , School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University , School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University , School of Medicine and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The Third Department of Internal Medicine, School of Medicine , Iwate Medical University and Related Hospitals
The First Department of Internal Medicine, Tohoku University , School of Medicine
The First Department of Internal Medicine, Tohoku University , School of Medicine
The First Department of Internal Medicine, Tohoku University , School of Medicine
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Division of Respiratory Disease, Iwaki Kyoritsu General Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
The Department of Internal Medicine, Juntendo University, School of Medicine
The Department of Internal Medicine, Juntendo University, School of Medicine
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Internal Medicine, Tokyo Women's Medical College
Department of Internal Medicine, Tokyo Women's Medical College
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
Department of Internal Medicine, Tokyo Kosei-Nenkin Hospital
Department of Internal Medicine, Tokyo Kosei-Nenkin Hospital
Department of Internal Medicine, Tokyo Kosei-Nenkin Hospital
Department of Internal Medicine, Institute of Medical Science, University of Tokyo
Department of Internal Medicine, Institute of Medical Science, University of Tokyo
Department of Internal Medicine, Institute of Medical Science, University of Tokyo
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Infections Laboratory, Kanagawa Prefectural Nursing and Hygienic School Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Yokohama Teishin Hospital
Department of Internal Medicine, Kawasaki Chuo Hospita
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine
The Second Department of Internal Medicine, Niigata University, School of Medicine
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Nagaoka Red Cross Hospital
Department of Internal Medicine, Koseiren Nagaoka Chuo Sogo Hospital
Department of Internal Medicine, Koseiren Nagaoka Chuo Sogo Hospital
Internal Medicine, Suibarago Hospital
Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
Division of Respiratory Diseases of Internal Medicine, Kanazawa Medical University, School of Medicine
Division of Respiratory Diseases of Internal Medicine, Kanazawa Medical University, School of Medicine
Division of Respiratory Diseases of Internal Medicine, Kanazawa Medical University, School of Medicine
The First Department of Internal Medicine, Nagoya University School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya University School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya University School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya University School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagoya University School of Medicine
The Second Department of Internal Medicine, Nagoya University School of Medicine
The Second Department of Internal Medicine, Nagoya University School of Medicine
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nara Medical University
The Second Department of Internal Medicine, Nara Medical University
The Second Department of Internal Medicine, Nara Medical University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Hiroshima National Sanatorium
Department of Internal Medicine, Hiroshima National Sanatorium
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University School of Health Sciences, Kyushu University
The Second Department of Internal Medicine, Fukuoka University, School of Medicine
Department of Internal Medicine, National Minami Fukuoka Hospital
Department of Internal Medicine, National Minami Fukuoka Hospital
Departmemt of Internal Medicine, Ohmuta National Sanatorium
Departmemt of Internal Medicine, Ohmuta National Sanatorium
Departmemt of Internal Medicine, Ohmuta National Sanatorium
Department of Internal Medicine, Saga Medical School
Department of Internal Medicine, Saga Medical School
Department of Internal Medicine, Saga Medical School
Department of Internal Medicine, Saga Medical School
Department of Internal Medicine, Saga Medical School
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
The First Department of Internal Medicine, Kumamoto University, Medical School
The First Department of Internal Medicine, Kumamoto University, Medical School
The First Department of Internal Medicine, Kumamoto University, Medical School
The First Department of Internal Medicine, Kumamoto University, Medical School
Department of Internal Medicine, Kumamoto Rosai Hospital
Department of Internal Medicine, Kumamoto Rosai Hospital
Department of Internal Medicine, Kumamoto Central Hospital
Department of Internal Medicine, Kumamoto Central Hospital
Department of Internal Medicine, Kumamoto Central Hospital
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
Department of Internal Medicine, National Miyazaki Higashi Hospital
Department of Internal Medicine, National Miyazaki Higashi Hospital
The First Department of Internal Medicine, School of Medicine, University of the Ryukyu
The First Department of Internal Medicine, School of Medicine, University of the Ryukyu
School of Medicine, University of Tokyo
Department of Clinical Pathology, Juntendo University, School of Medicine
Department of Clinical Pathology, Juntendo University, School of Medicine
1986 Volume 60 Issue 9 Pages 1052-1077
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The clinical efficacy and safety of T-2588 were compered with those of cefaclor (CCL) in patients with chronic respiratory tract infection by a double-blind study. Administration was performed by oral for a fixed period of 14 days and the daily dosage was fixed at 600 mg for T-2588or 750 mg for CCL.
The following results were obtained.
1) Clinical efficacy rate by committee judgement was 83.6% for T-2588 and 56.3% for CCL, respectively. The statistical analysis of these results revealed that T-2588 was significantly moreeffective than CCL.
2) The results of the clinical efficacy judged by the doctors in charge was similar to efficacy judged by the committee.
3) The bacteriological eradication rate of causative organisms by committee judgement was 77.6% for T-2588 and 52.4% for CCL, respectively. Furthermore, eradication rate of T-2588 in H. influenzae was significantly superior to that of CCL.
4) With respect to the rate of improvement of clinical signs, symptoms and laboratory findings the T-2588 was superior to the CCL in the improvement for cough, sputum volume, sputum property, rale and ESR.
5) The incidence rate of side effect was 4.5% for T-2588 and 6.5% for CCL, respectively, and these were no significant difference between the two drug group. Abnormal laboratory findings were observed at the rate of 15.5% for T-2588 and 5.8% for CCL, respectively. Incidence rate ofabnormal laboratory findings was significantly higher in T-2588 and the most frequent finding was eosinophilia.
6) Usefulness rate judged by committee members for T-2588 and CCL were 80.2% and 55.7%, respectively, and these were significantly different statistically.
7) The results of clinical usefulness judged by the doctors in charge were similar to the usefulness judged by committee. These results indicated that T-2588 is useful drug for the treatment of chronic respiratory tract infections.