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Personal exposure to PM2.5-bound heavy metals associated with cardiopulmonary function in general population

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Abstract

To better understand the cardiopulmonary alterations associated with personal exposed PM2.5-bound heavy meals, we conducted a cross-sectional study in 2018 on 54 general residents. For each subject, PM2.5 exposure filter was collected by a low-volume sampler for 24 h; blood and urine samples were collected subsequently. Heavy metals in PM2.5, blood, and urine samples were determined by inductively coupled plasma mass spectrometry method. PM2.5-bound Mn, Cd, Sb, Pb, and Ni levels were 20.5, 9.27, 9.59, 28.3, and 16.9 ng/m3, respectively. The distribution of these metals followed the order: Pb (33.47%) > Mn (24.24%) > Ni (19.99%) > Sb (11.34%) > Cd (10.96%). The distribution of heavy meals in PM2.5, blood, and urine differed from each other. PM2.5-bound Cd, Pb levels were positively correlated with blood Cd, Pb levels (r = 0.323, r = 0.334, p < 0.05), respectively. PM2.5-bound Cd level was significantly higher in smoking group than non-smoking group (28.8 vs. 7.27 ng/m3, p < 0.01), same as Sb level (12.0 vs. 9.34 ng/m3, p < 0.01). Cd and Pb exposure might interact with cardiovascular function through autonomic regulation. No significant correlation was observed between metal exposure and pulmonary function. In conclusion, our data suggested that personal exposure to specific PM2.5-bound heavy metals might interact with profound cardiovascular alterations.

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Acknowledgments

We are grateful to all the people who contributed to this work.

Funding

This study was supported by the Foundation of the Ministry of Health and Science and Technology (WKJ-ZJ-1606), the National Natural Science Foundation of China (81502786), the Science and Technology Foundation of Zhejiang Province (2014C03025), and Medical Scientific Research of Zhejiang Province (2012KYA047, 2015KYA055, 2016KYB062, 2018KY337, 2020KY514).

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Authors and Affiliations

  1. Zhejiang Provincial Center for Disease Control and Prevention, 3399 Bin Sheng Road, Binjiang District, Hangzhou, 310051, China

    Peiwei Xu, Shengliang He, Lizhi Wu, Yuan Chen, Dandan Xu, Weizhong Chen, Zhijian Chen, Xiaofeng Wang & Xiaoming Lou

  2. Jinhua Center for Disease Control and Prevention, Jinou Road 1366, Jinhua, 321002, China

    Xiaoqing He, Jinbin Luo, Qiang Chen & Zuoyi Wang

  3. Ningbo Center for Disease Control and Prevention, Yongfeng Road 237, Ningbo, 315010, China

    Aihong Wang & Beibei Lu

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  1. Peiwei Xu
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  2. Xiaoqing He
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  15. Xiaoming Lou
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Correspondence to Xiaoming Lou.

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The study was approved by the Ethics and Human Subject Committee of Zhejiang Provincial Center for Disease Control and Prevention.

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The findings and conclusions in this article are those of the authors and do not necessarily represent the official views of the Zhejiang Provincial Center for Disease Control and Prevention.

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Responsible Editor: Lotfi Aleya

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Xiaoqing He is Co-first author

Electronic supplementary material

ESM 1

Appendix A. Supplementary data: The detection limit of heavy metals in different samples; the matrix diagrams of heavy metals among different sample categories; the exposure levels of PM2.5 bound heavy metals in different smoking groups. (DOCX 155 kb)

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Xu, P., He, X., He, S. et al. Personal exposure to PM2.5-bound heavy metals associated with cardiopulmonary function in general population. Environ Sci Pollut Res 28, 6691–6699 (2021). https://doi.org/10.1007/s11356-020-11034-1

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