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Homozygosity for Factor V Leiden mutation and ischemic stroke: two case-reports and review of the literature

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References

  1. Bauer KA, Griffin JH (1995) Factor V Leiden and Thrombophilia. N Engl J Med 332:1383

    PubMed  Google Scholar 

  2. De Lucia D, Cerbone M, Belli A, et al. (1996) Resistance to activated protein C in adults with a history of juvenile transient ischemic attacks. Thromb Haemost 76:627–631

    CAS  PubMed  Google Scholar 

  3. Emmerich J, Poirier O, Evans A, et al. (1995) Myocardial infarction, Arg 506 to Gln factor V mutation and activated protein C resistance. Lancet 35:321

    Google Scholar 

  4. Emmerich J, Alhenc-Gelas M, Ailaud MF, et al. (1997) Clinical features in 36 patients homozygous for the ARG 506 to GLN factor V mutation. Thromb Haemost 4:620–623

    Google Scholar 

  5. Heinrich J, Budde T, Assmann G (1995) Mutation in the factor V gene and the risk of myocardial infarction. N Engl J Med 333:881

    CAS  Google Scholar 

  6. Holm J, Zöller B, Svensson PJ, Berntorp E, Erhardt L, Dahlbäck B (1994) Myocardial infarction associated with homozygous resistance to activated protein C Lancet 344:952–953

    CAS  Google Scholar 

  7. Hopmeier P, Krugluger W (1994) Factor V Leiden and thrombophilia. N Engl J Med 332:1381–1382

    Google Scholar 

  8. Kim RJ, Becker R (2003) Association between factor V leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: A meta-analysis of published studies. Am Heart J 146:948–957

    CAS  PubMed  Google Scholar 

  9. Lalouschek W, Aull S, Serles W, Schnider P, et al. (1999) C677T MTHFR mutation and factor V leiden mutation in patients with TIA/minor stroke: A case-control study. Thromb Res 93:61–69

    CAS  PubMed  Google Scholar 

  10. Nowak-Göttl U, Sträter R, Heinecke A, Junker R, Koch HG, Schuierer G, von Eckardstein A (1999) Lipoprotein (a) and genetic polymorphisms of clotting factor V, Prothrombin and Methylenetetrahydrofolate Reductase are risk factors of spontaneous ischemic stroke in childhodd Blood 94:3678–3682

    PubMed  Google Scholar 

  11. Simoni P, Scudeller A, Girolami A (1994) Factor V Leiden and Thrombophilia. N Engl J Med 332:1381–1382

    Google Scholar 

  12. The Procare Group (2000) Comparison of thrombotic risk between 85 homozygotes and 481 heterozygotes carriers of the factor V Leiden mutation: retrospective analysis from the Procare Study. Blood Coagul Fibrinolysis 11:511–518

    PubMed  Google Scholar 

  13. Whitlock JA, Janco RL, Philips JA (1089) Inherited hypercoagulable states in children. Am J Pediatr Hem Oncol 11:170–173

    Google Scholar 

  14. Weih M, Junge-Hülsing J, Mehraein S, Ziemer S, Einhäupl KM (2000) Hereditäre Thrombophilien bei ischämischen Schlaganfall und Sinusvenenthrombosen. Der Nervenarzt 71:936–945

    CAS  PubMed  Google Scholar 

  15. Zenz W, Bodo Z, Plotho J, et al. (1998) Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke. Thromb Haemost 80:763–766

    CAS  PubMed  Google Scholar 

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Correspondence to Achim Allroggen MD.

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Allroggen, A., Dittrich, R., Ritter, M. et al. Homozygosity for Factor V Leiden mutation and ischemic stroke: two case-reports and review of the literature. J Neurol 251, 1406–1407 (2004). https://doi.org/10.1007/s00415-004-0542-9

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  • DOI: https://doi.org/10.1007/s00415-004-0542-9

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