Abstract
A woman with a multiple-hormone-producing pancreatic islet cell tumor with hepatic metastases and with recurrent hypoglycemic attacks, was treated with steptozotocin. After this treatment, the elevated serum levels of insulin, C-peptide, glucagon and serotonin fell markedly and the low level of fasting blood glucose returned to normal. In accordance with these hormonal changes, scintiscan and CT scan revealed marked regression of the metastatic tumors in the liver. She is alive at this writing, five years after the streptozotocin treatment. Streptozotocin should thus be considered for treatment of malignant islet cell carcinoma with liver metastases and which is not amenable to surgery.
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References
Murray-Lyon, IM, Eddleston ALWF, Williams R, Brown M, Hogbin BM, Bennett A, Edwards JC, Jaylon KW. Treatment of multiple-hormone-producing malignant islet-cell tumor with streptozotocin. Lancet 1968; 2: 895–898.
Herbai G, Lundin A. Treatment of malignant metastatic pancreatic insulinoma with streptozotocin. Acta Med Scand 1976; 200: 447–452.
Gefel A, Flatau, E, Ayalon D, Papo J, Loewenthal M. Malignant metastatic insulinoma treated with streptozotocin. Clin Endocrinol 1975; 4: 461–468.
Broder LE, Carter SK. Pancreatic islet cell carcinoma; II. Results of therapy with streptozotocin in 52 patients. Ann Intern Med 1973; 79; 108–118.
Reusser F. Mode of action of streptozotocin. J Bact 1971; 105: 580–588.
Rosenkranz HS, Carr HS. Differneces in the action nitrosomethylurea and streptozotocin. Cancer Res 1970; 30: 112–117.
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Murata, E., Tashiro, S. & Hiraoka, T. Streptozotocin effective for treating multiple-hormone-producing malignant islet cell tumor. The Japanese Journal of Surgery 15, 63–67 (1985). https://doi.org/10.1007/BF02469860
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DOI: https://doi.org/10.1007/BF02469860