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  • Articles  (2,331)
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  • Articles  (2,331)
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  • 1
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    Editorial Board (2016)
    Elsevier
    Details
    Publication Date: 2016-10-14
    Description: Publication date: 21 December 2015 Source: FEBS Letters, Volume 589, Issue 24, Part A
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 2
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    Editorial Board (2016)
    Elsevier
    Details
    Publication Date: 2016-10-14
    Description: Publication date: 21 December 2015 Source: FEBS Letters, Volume 589, Issue 24, Part B
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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  • 3
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    Calcium ions inhibit reduction of heme a in bovine cytochrome c oxidase (2015)
    Elsevier
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    Publication Date: 2015-12-02
    Description: Publication date: Available online 1 December 2015 Source: FEBS Letters Author(s): Artem V. Dyuba, Tatiana Vygodina, Natalia Azarkina, Alexander A. Konstantinov The effect of Ca 2+ on the rate of heme a reduction by dithionite and hexaammineruthenium (RuAm) was studied in the cyanide-complexed bovine cytochrome oxidase (CcO). The rate of heme a reduction is proportional to RuAm concentration below 300 μM with k v of 0.53 × 10 6 M −1 s −1 . Ca 2+ inhibits the rate of heme a reduction by dithionite by ∼25%. As the reaction speeds up with increased concentrations of RuAm, the inhibition by Ca 2+ disappears. The inhibition of heme a reduction may contribute to recently described partial inhibition of CcO by Ca 2+ in the enzymatic assays. The inhibitory effect of Ca 2+ on heme a reduction indicates that ET through heme a may be coupled to proton movement in the exit part of the proton channel H.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 4
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    Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli (2015)
    Elsevier
    Details
    Publication Date: 2015-12-01
    Description: Publication date: Available online 30 November 2015 Source: FEBS Letters Author(s): Cristina Ortiz, Danguole Kureisaite-Ciziene, Florian Schmitz, Stephen H. McLaughlin, Miguel Vicente, Jan Löwe Bacterial cell division involves a contractile ring that organises downstream proteins at the division site and which contains the tubulin homologue FtsZ. ZapC has been discovered as a non-essential regulator of FtsZ. It localises to the septal ring and deletion of zapC leads to a mild phenotype, while overexpression inhibits cell division. Interference with cell division is facilitated by an interaction with FtsZ. Here, we present the 2.9 Å crystal structure of ZapC from Escherichia coli . ZapC forms a dimer and comprises two domains that belong to the Royal superfamily of which many members bind methylated arginines or lysines. ZapC contains an N-terminal chromo-like domain and a Tudor-like C-terminal domain. We show by ITC that ZapC binds the C-terminal tail of FtsZ.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 5
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    Mass spectrometry cancer data classification using wavelets and genetic algorithm (2015)
    Elsevier
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    Publication Date: 2015-12-01
    Description: Publication date: Available online 30 November 2015 Source: FEBS Letters Author(s): Thanh Nguyen, Saeid Nahavandi, Douglas Creighton, Abbas Khosravi This paper introduces a hybrid feature extraction method applied to mass spectrometry (MS) data for cancer classification. Haar wavelets are employed to transform MS data into orthogonal wavelet coefficients. The most prominent discriminant wavelets are then selected by genetic algorithm (GA) to form feature sets. The combination of wavelets and GA yields highly distinct feature sets that serve as inputs to classification algorithms. Experimental results show the robustness and significant dominance of the wavelet-GA against competitive methods. The proposed method therefore can be applied to cancer classification models that are useful as real clinical decision support systems for medical practitioners.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 6
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    Insights into the behavioral difference of water in the presence of GM1 (2015)
    Elsevier
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    Publication Date: 2015-12-01
    Description: Publication date: Available online 29 November 2015 Source: FEBS Letters Author(s): Ipsita Basu, Moutusi Manna, Chaitali Mukhopadhyay Studies on the structure and dynamics of interfacial water, emphasizing on the properties of water near the surface of biomolecules, are well reported, but there is a lack of evidence on the behavior of water near a comparatively rough surface containing molecules with a bulky head group like GM1. In this report we comparatively analyze the structure and dynamics of water as a function of distance from the lipid head group in GM1 containing lipid bilayers, with the lipid bilayers where GM1 is not present. This approach effectively demonstrates the behavioral difference and hence delayed convergence from bound water to bulk water in the presence of GM1 compared to a relatively smooth surface.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 7
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    The Arabidopsis thaliana K+-uptake permease 7 (AtKUP7) contains a functional cytosolic adenylate cyclase catalytic centre (2015)
    Elsevier
    Details
    Publication Date: 2015-11-29
    Description: Publication date: Available online 27 November 2015 Source: FEBS Letters Author(s): Inas Al-Younis, Aloysius Wong, Chris Gehring Adenylate Cyclases (ACs) catalyze the formation of the second messenger cyclic adenosine 3′, 5′-monophosphate (cAMP) from adenosine 5’-triphosphate (ATP). Although cAMP is increasingly recognized as an important signaling molecule in higher plants, ACs have remained somewhat elusive. Here we used a search motif derived from experimentally tested guanylyl cyclases (GCs), substituted the residues essential for substrate specificity and identified the Arabidopsis thaliana K + -uptake permease 7 (AtKUP7) as one of several candidate ACs. Firstly, we show that a recombinant N-terminal, cytosolic domain of AtKUP7 1-100 is able to complement the AC-deficient mutant cyaA in Escherichia coli and thus restoring the fermentation of lactose, and secondly, we demonstrate with both enzyme immunoassays and mass spectrometry that a recombinant AtKUP7 1-100 generates cAMP in vitro .
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 8
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    Unusual effects of crowders on heme retention in myoglobin (2015)
    Elsevier
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    Publication Date: 2015-11-29
    Description: Publication date: Available online 27 November 2015 Source: FEBS Letters Author(s): Jayanta Kundu, Uddipan Kar, Saurabh Gautam, Sandip Karmakar, Pramit K. Chowdhury Myoglobin (Mb) undergoes pronounced heme loss under denaturing conditions wherein the proximal histidine gets protonated. Our data show that macromolecular crowding agents (both synthetic and protein based) can appreciably influence the extent of heme retention in Mb. Interestingly, glucose and sucrose, the monomeric constituents of dextran and ficoll-based crowders were much more effective in preventing heme dissociation of Mb, albeit, at much higher concentrations. The protein crowders BSA and lysozyme show very interesting results with BSA bringing about the maximum heme retention amongst all the crowding agents used while lysozyme induced heme dissociation even in the native state of Mb. The stark difference that these protein crowders exhibit when interacting with the heme protein is a testament to the varied interaction potentials that a test protein might be exposed to in the physiological (crowded) milieu. Graphical abstract
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 9
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    Role of cytosolic and calcium independent phospholipases A2 in insulin secretion impairment of INS-1E cells infected by S. aureus (2015)
    Elsevier
    Details
    Publication Date: 2015-11-28
    Description: Publication date: Available online 26 November 2015 Source: FEBS Letters Author(s): N. Caporarello, M. Salmeri, M. Scalia, C. Motta, C. Parrino, L. Frittitta, M. Olivieri, M.A. Toscano, C.D. Anfuso, G. Lupo Cytosolic PLA 2 (cPLA 2 ) and Ca 2+ -independent PLA 2 (iPLA 2 ) play a significant role in insulin β-cells secretion. Bacterial infections may be responsible of the onset of diabetes. The mechanism by which S. aureus infection of INS-1 cells alters glucose-induced insulin secretion has been examined. After acute infection, insulin secretion and PLA 2 activities significantly increased. Moreover, increased expressions of phospho-cPLA 2 , phospho-PKCα and phospho-ERK 1/2 were observed. Chronic infection causes a decrease in insulin release and a significant increase of iPLA 2 and COX-2 protein expression. Moreover, insulin secretion in infected cells could be restored using specific si RNAs against iPLA 2 isoform and specific COX-2 inhibitor.
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 10
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    Characterization and crystal structure determination of β-1,2-mannobiose phosphorylase from Listeria innocua (2015)
    Elsevier
    Details
    Publication Date: 2015-11-28
    Description: Publication date: Available online 26 November 2015 Source: FEBS Letters Author(s): Tomohiro Tsuda, Takanori Nihira, Kazuhiro Chiku, Erika Suzuki, Takatoshi Arakawa, Mamoru Nishimoto, Motomitsu Kitaoka, Hiroyuki Nakai, Shinya Fushinobu Glycoside hydrolase family 130 consists of phosphorylases and hydrolases for β-mannosides. Here, we characterized β-1,2-mannobiose phosphorylase from Listeria innocua (Lin0857) and determined its crystal structures complexed with β-1,2-linked mannooligosaccharides. β-1,2-Mannotriose was bound in a U-shape, interacting with a phosphate analog at both ends. Lin0857 has a unique dimer structure connected by a loop, and a significant open-close loop displacement was observed for substrate entry. A long loop, which is exclusively present in Lin0857, covers the active site to limit the pocket size. A structural basis for substrate recognition and phosphorolysis was provided.
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    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology , Physics
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