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  • 1
    Electronic Resource
    Electronic Resource
    Delayed hypersensitivity reactions in the intestinal tract (1969)
    Springer
    Digestive diseases and sciences 14 (1969), S. 385-393 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A chronic delayed hypersensitivity reaction was produced in the pig stomach. In skin-sensitized animals 2–4 dinitrochlorobenzene (DNCB) in adhesive paste produced mucosal ulceration with intestinalization, edema, and marked round-cell infiltration of the submucosa, vascular congestion, perivascular cuffing, and fibrinoid arteriolar changes. When pigs that were not skin-sensitized were given DNCB in adhesive paste, no mucosal ulceration was seen. A similar but less intense cellular infiltrate and vascular change was present. Circulating antibodies to DNCB showed no relationship to the morphological lesion, while parietal cell antibody immunofluorescent titers parallel the intensity of the tissue response. Under the conditions of this experiment, parietal cell antibodies are not involved in the pathogenesis of the mucosal lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239356
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Delayed hypersensitivity reactions in the gastrointestinal tract (1969)
    Springer
    Digestive diseases and sciences 14 (1969), S. 853-863 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen niniature swine were skin-sensitized to 2–4 dinitrochlorobenzene (DNCB) and had a colostomy in the midtransverse colon. All were given DNCB in adhesive paste 3 times weekly for 6 months, through the colostomy. In addition 6 animals received Freund's complete adjuvant, 6 were given E. coli endotoxin, and 4 were given neostigmine 2 times weekly for 6 months. The morphological changes produced in all animals were those of microscopic ulceration and partial glandular destruction. The lamina propria showed a chronic inflammatory infiltrate. The vessels showed perivascular congestion. The adjuvant group seemed to have a more grossly intense lesion. In the neostigmine group, crypt abscesses were found in all pigs, the first production of such lesions in an experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233206
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    Paper (German National Licenses)
    Fulltext
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