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1

Online-Ressource

Blood Libel : The Ritual Murder Accusation at the Limit of Jewish History (2012)

Johnson, Hannah [VerfasserIn]

Ann Arbor : University of Michigan Press

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Schlagwort(e): Electronic books

Beschreibung / Inhaltsverzeichnis: The first book investigating the recent historiography of the ritual murder accusation.

Materialart: Online-Ressource

Seiten: 1 online resource (193 pages)

ISBN: 9780472902545

URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=7007854

DDC: 305.892/4009

Sprache: Englisch

Anmerkung: Description based on publisher supplied metadata and other sources

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2

Online-Ressource

Blood Libel : The Ritual Murder Accusation at the Limit of Jewish History (2012)

Johnson, Hannah [VerfasserIn]

Ann Arbor : University of Michigan Press

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Details Verfügbarkeit

Beschreibung / Inhaltsverzeichnis: The first book investigating the recent historiography of the ritual murder accusation.

Materialart: Online-Ressource

Seiten: 1 online resource (0 pages)

Ausgabe: 1st ed.

ISBN: 9780472028436

URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=30394534

DDC: 305.892/4009

Sprache: Englisch

Anmerkung: Description based on publisher supplied metadata and other sources

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3

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Rule learning enhances structural plasticity of long-range axons in frontal cortex (2016)

Carolyn M. Johnson; Hannah Peckler; Lung-Hao Tai; Linda Wilbrecht

Nature Publishing Group (NPG)

In: Nature Communications

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Publikationsdatum: 2016-03-08

Beschreibung: Article The orbitofrontal cortex is associated with foraging behaviour yet the structural changes underlying such rule-based learning remain unclear. Here, the authors imaged OFC axons throughout a digging-based odour discrimination task and found correlations between the rate of bouton turnover and the behavioural strategies of individual mice. Nature Communications doi: 10.1038/ncomms10785 Authors: Carolyn M. Johnson, Hannah Peckler, Lung-Hao Tai, Linda Wilbrecht

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Nature Publishing Group (NPG)

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Rule learning enhances structural plasticity of long-range axons in frontal cortex (2016)

Carolyn M. Johnson; Hannah Peckler; Lung-Hao Tai; Linda Wilbrecht

Nature Publishing Group (NPG)

In: Nature Communications

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Publikationsdatum: 2016-03-08

Beschreibung: Article The orbitofrontal cortex is associated with foraging behaviour yet the structural changes underlying such rule-based learning remain unclear. Here, the authors imaged OFC axons throughout a digging-based odour discrimination task and found correlations between the rate of bouton turnover and the behavioural strategies of individual mice. Nature Communications doi: 10.1038/ncomms10785 Authors: Carolyn M. Johnson, Hannah Peckler, Lung-Hao Tai, Linda Wilbrecht

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Nature Publishing Group (NPG)

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5

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Experimental verification of theoretical equations for acoustic radiation force on compressible spherical particles in traveling waves (2016)

Kennita A. Johnson, Hannah R. Vormohr, Alexander A. Doinikov, Ayache Bouakaz, C. Wyatt Shields, IV, Gabriel P. López, and Paul A. Dayton

American Physical Society (APS)

In: Physical Review E

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Publikationsdatum: 2016-05-18

Beschreibung: Author(s): Kennita A. Johnson, Hannah R. Vormohr, Alexander A. Doinikov, Ayache Bouakaz, C. Wyatt Shields, IV, Gabriel P. López, and Paul A. Dayton Acoustophoresis uses acoustic radiation force to remotely manipulate particles suspended in a host fluid for many scientific, technological, and medical applications, such as acoustic levitation, acoustic coagulation, contrast ultrasound imaging, ultrasound-assisted drug delivery, etc. To estimate t… [Phys. Rev. E 93, 053109] Published Tue May 17, 2016

Schlagwort(e): Fluid Dynamics

Print ISSN: 1539-3755

Digitale ISSN: 1550-2376

Thema: Physik

Publiziert von American Physical Society (APS)

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P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells (2017)

Mahamat Babagana, Sydney Johnson, Hannah Slabodkin, Wiam Bshara, Carl Morrison, Eugene S. Kandel

Wiley-Blackwell

In: Molecular Carcinogenesis

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Publikationsdatum: 2017-01-05

Beschreibung: BRAF is a commonly mutated oncogene in various human malignancies and a target of a new class of anti-cancer agents, BRAF-inhibitors (BRAFi). The initial enthusiasm for these agents, based on the early successes in the management of metastatic melanoma, is now challenged by the mounting evidence of intrinsic BRAFi-insensitivity in many BRAF-mutated tumors, by the scarcity of complete responses, and by the inevitable emergence of drug resistance in initially responsive cases. These setbacks put an emphasis on discovering the means to increase the efficacy of BRAFi and to prevent or overcome BRAFi-resistance. We explored the role of p21-activated kinases (PAKs), in particular PAK1, in BRAFi response. BRAFi lowered the levels of active PAK1 in treated cells. An activated form of PAK1 conferred BRAFi-resistance on otherwise sensitive cells, while genetic or pharmacologic suppression of PAK1 had a sensitizing effect. While activation of AKT1 and RAC1 proto-oncogenes increased BRAFi-tolerance, the protective effect was negated in the presence of PAK inhibitors. Furthermore, combining otherwise ineffective doses of PAK- and BRAF-inhibitors synergistically affected intrinsically BRAFi-resistant cells. Considering the high incidence of PAK1 activation in cancers, our findings suggests PAK inhibition as a strategy to augment BRAFi therapy and overcome some of the well-known resistance mechanisms. This article is protected by copyright. All rights reserved

Print ISSN: 0899-1987

Digitale ISSN: 1098-2744

Thema: Medizin

Publiziert von Wiley-Blackwell

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Identification of the vascular plants of Churchill, Manitoba, using a DNA barcode library (2012)

Maria Kuzmina; Karen Johnson; Hannah Barron; Paul Hebert

BioMed Central

In: BMC Ecology

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Publikationsdatum: 2012-11-29

Beschreibung: Background: Because arctic plant communities are highly vulnerable to climate change, shifts in their composition require rapid, accurate identifications, often for specimens that lack diagnostic floral characters. The present study examines the role that DNA barcoding can play in aiding floristic evaluations in the arctic by evaluating the effectiveness of the core plant barcode regions (rbcL, matK) and a supplemental ribosomal DNA (ITS2) marker for a well-studied flora near Churchill, Manitoba. Results: This investigation examined 900 specimens representing 312 of the 354 species of vascular plants known from Churchill. Sequencing success was high for rbcL: 95% for fresh specimens and 85% for herbarium samples (mean age 20 years). ITS2 worked equally well for the fresh and herbarium material (89% and 88%). However, sequencing success was lower for matK, despite two rounds of PCR amplification, which reflected less effective primer binding and sensitivity to the DNA degradation (76% of fresh, 45% of herbaria samples). A species was considered as taxonomically resolved if its members showed at least one diagnostic difference from any other taxon in the study and formed a monophyletic clade. The highest species resolution (69%) was obtained by combining information from all three genes. The joint sequence information for rbcL and matK distinguished 54% of 286 species, while rbcL and ITS2 distinguished 63% of 285 species. Discrimination of species within Salix, which constituted 8% of the flora, was particularly problematic. Despite incomplete resolution, the barcode results revealed 22 misidentified herbarium specimens, and enabled the identification of field specimens which were otherwise too immature to identify. Although seven cases of ITS2 paralogy were noted in the families Cyperaceae, Juncaceae and Juncaginaceae, this intergenic spacer played an important role in resolving congeneric plant species at Churchill. Conclusions: Our results provided fast and cost-effective solution to create a comprehensive, effective DNA barcode reference library for a local flora.

Digitale ISSN: 1472-6785

Thema: Biologie

Publiziert von BioMed Central

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