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Digitale Medien

Characterization of Newly Formed and Aged Granules in the Neurohypophysis (1986)

Nordmann, Jean J. ; Cazalis, Monique

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 47 (1986), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract Neurosecretory granules from the rat and bovine neurohypophysis were isolated and some of their biochemical and biophysical properties studied. Neurosecretory granules (NSG) from rat neurohypophysis were labeled, in vivo, with [35S]cysteine and isolated on isoosmotic gradients. Whereas 1 day after labeling most of the radioactivity was found in the lower part of the gradient, 35 days later the isotope was also located in the lighter NSG-containing fraction. Different analytical procedures showed that the lighter fraction, both in bovine and rat NSG, contain more subpopulations of neurophysin-like material than the heavier fraction. The first material to be released during stimulation of secretion, in vivo or in vitro, is mobilized from the heavy NSG. Isolation of rat NSG, at different times during and after dehydration of the animals, reveals that the newly synthesized material is found in the heavy NSG-containing fraction. Furthermore, the results indicate that the newly synthesized NSG are more resistant to lysis than the lighter granules. The results are discussed in relation to the maturation and degradation processes of the granule content and to the functional state of the NSG.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb00791.x

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Digitale Medien

Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis (1987)

Dayanithi, Govindan ; Cazalis, Monique ; Nordmann, Jean J.

[s.l.] : Nature Publishing Group

Nature 325 (1987), S. 813-816

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Figure 1 illustrates the time course of vasopressin (AVP) and oxytocin (OT) release from isolated nerve terminals in the presence or absence of 10~7 M relaxin. An increase in hormone secretion was induced by depolarizing the isolated nerve terminals (neurosecretosomes) with 100 mM K+ for 10 min. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/325813a0

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Digitale Medien

Are opioid peptides co-localized with vasopressin or oxytocin in the neural lobe of the rat? (1986)

Nordmann, Jean J. ; Cazalis, Monique ; Dayanithi, Govindan ; [weitere]

Springer

Cell & tissue research 246 (1986), S. 177-182

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ISSN: 1432-0878

Schlagwort(e): Vasopressin ; Oxytocin ; Opioid peptides ; Neurosecretion ; Neural lobe ; Co-localization ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The content of vasopressin, oxytocin, neurophysin, leucine-enkephalin, methionine-enkephalin, dynorphin-(1–13), and α-neoendorphin in the rat neurohypophysis was measured after different periods of dehydration and after depolarisation of isolated neural lobes and of neurosecretory nerve endings. The rates at which the amount of neurohypophysial hormone and opioid peptides decreased, and the changes in the ratios between the amount of vasopressin or oxytocin and opioid peptide in the neurohypophysis after dehydration and in the incubation medium after depolarization in vitro cast some doubt on, and can be explained by mechanisms other than co-localisation of the different peptides.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00219015

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