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  • 1: advanced search Author, Corporation: Haeckel, Matthias   :   (Online articles)  —  0 hits    Redo Search Permalink feed icon
  • 2: advanced search Author, Corporation: Carina van der Laan; Arif Budiman; Judith A. Verstegen; Stefan C. Dekker; Wiwin Effendy; André P. C. Faaij; Arif Data Kusuma; Pita A. Verweij   :   (Online articles)  —  0 hits    Redo Search Permalink feed icon
  • 3: advanced search Author, Corporation: Kusumoto, Tatsuya   :   —  0 hits    Redo Search Permalink feed icon
  • 4: advanced search Author, Corporation: Evans, David   :   (Online articles)  —  0 hits    Redo Search Permalink feed icon
  • 5: advanced search Author, Corporation: Hastings, T.   :   —  6 hits    Redo Search Permalink feed icon
  • 6: advanced search Author, Corporation: Schefuß, Enno   :   —  120 hits    Redo Search Permalink feed icon
  • 7: advanced search Author, Corporation: Hoffmann, J.   :   (Online articles)  —  1042 hits    Redo Search Permalink feed icon
  • 8: advanced search Author, Corporation: Wang, Xiaoming   :   —  1 hit    Redo Search Permalink feed icon
  • 9: advanced search Author, Corporation: Werner, Friedrich   :   —  1 hit    Redo Search Permalink feed icon
  • 10: advanced search Author, Corporation: Weber, Tom   :   —  1 hit    Redo Search Permalink feed icon
  • 11: advanced search Author, Corporation: Lenz, Jürgen   :   —  6 hits    Redo Search Permalink feed icon
  • 12: advanced search Author, Corporation: Fischer, Jürgen 1950-   :   (Online articles)  —  0 hits    Redo Search Permalink feed icon
  • 13: advanced search Author, Corporation: Rödenbeck, Christian   :   (Online articles)  —  79 hits    Redo Search Permalink feed icon
  • 14: advanced search Author, Corporation: Harrison, Sandy P.   :   —  9 hits    Redo Search Permalink feed icon
  • 15: advanced search Author, Corporation: LeGrande, Allegra N.   :   —  10 hits    Redo Search Permalink feed icon

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  • 1
    Online Resource
    Online Resource
    Unawareness of being prescribed medications for diabetes and incident cardiovascular disease
    Elsevier BV ; 2024
    In:  Journal of Cardiology ( 2024-4)
    Details
    In: Journal of Cardiology, Elsevier BV, ( 2024-4)
    Type of Medium: Online Resource
    ISSN: 0914-5087
    URL: Article
    DOI: 10.1016/j.jjcc.2024.03.011
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2422407-8
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  • 2
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    Age prediction from coronary angiography using a deep neural network: Age as a potential label to extract prognosis-related imaging features
    Public Library of Science (PLoS) ; 2022
    In:  PLOS ONE Vol. 17, No. 10 ( 2022-10-27), p. e0276928-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2022-10-27), p. e0276928-
    Abstract: Coronary angiography (CAG) is still considered the reference standard for coronary artery assessment, especially in the treatment of acute coronary syndrome (ACS). Although aging causes changes in coronary arteries, the age-related imaging features on CAG and their prognostic relevance have not been fully characterized. We hypothesized that a deep neural network (DNN) model could be trained to estimate vascular age only using CAG and that this age prediction from CAG could show significant associations with clinical outcomes of ACS. A DNN was trained to estimate vascular age using ten separate frames from each of 5,923 CAG videos from 572 patients. It was then tested on 1,437 CAG videos from 144 patients. Subsequently, 298 ACS patients who underwent percutaneous coronary intervention (PCI) were analysed to assess whether predicted age by DNN was associated with clinical outcomes. Age predicted as a continuous variable showed mean absolute error of 4 years with R squared of 0.72 ( r = 0.856). Among the ACS patients stratified by predicted age from CAG images before PCI, major adverse cardiovascular events (MACE) were more frequently observed in the older vascular age group than in the younger vascular age group (p = 0.017). Furthermore, after controlling for actual age, gender, peak creatine kinase, and history of heart failure, the older vascular age group independently suffered from more MACE (hazard ratio 2.14, 95% CI 1.07 to 4.29, p = 0.032). The vascular age estimated based on CAG imaging by DNN showed high predictive value. The age predicted from CAG images by DNN could have significant associations with clinical outcomes in patients with ACS.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
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    DOI: 10.1371/journal.pone.0276928
    DOI: 10.1371/journal.pone.0276928.g001
    DOI: 10.1371/journal.pone.0276928.g002
    DOI: 10.1371/journal.pone.0276928.g003
    DOI: 10.1371/journal.pone.0276928.g004
    DOI: 10.1371/journal.pone.0276928.g005
    DOI: 10.1371/journal.pone.0276928.t001
    DOI: 10.1371/journal.pone.0276928.t002
    DOI: 10.1371/journal.pone.0276928.t003
    DOI: 10.1371/journal.pone.0276928.t004
    DOI: 10.1371/journal.pone.0276928.s001
    DOI: 10.1371/journal.pone.0276928.s002
    DOI: 10.1371/journal.pone.0276928.r001
    DOI: 10.1371/journal.pone.0276928.r002
    DOI: 10.1371/journal.pone.0276928.r003
    DOI: 10.1371/journal.pone.0276928.r004
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2022
    detail.hit.zdb_id: 2267670-3
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  • 3
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    Comparison of incident hypertension between SGLT2 inhibitors vs. DPP4 inhibitors
    Springer Science and Business Media LLC ; 2024
    In:  Hypertension Research
    Details
    In: Hypertension Research, Springer Science and Business Media LLC
    Abstract: Although several randomized clinical trials have reported the potential benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in reducing blood pressure (BP), whether SGLT2i can reduce incident hypertension is unknown. We analyzed individuals with diabetes who were newly prescribed SGLT2i or dipeptidyl peptidase 4 inhibitors (DPP4i) in a large-scale epidemiological database. The primary outcome was the incidence of hypertension. A propensity score matching algorithm was employed to compare the subsequent development of hypertension between the SGLT2i and DPP4i groups. After propensity score matching, 5708 well-balanced pairs of SGLT2i and DPP4i users were identified. SGLT2i administration was associated with a reduced risk of hypertension (HR 0.91, 95% CI: 0.84–0.97). The advantage of SGLT2i use over DPP4i use for incident hypertension was generally consistent in several sensitivity analyses, and subgroup analyses showed that SGLT2i use was significantly associated with a lower risk of hypertension in men, patients with baseline HbA1c of 〈 7.5%, and baseline systolic blood pressure ≥127 mmHg. Our investigation using nationwide real-world data demonstrated the potential advantage of SGLT2i over DPP4i in reducing the development of hypertension in individuals with diabetes.
    Type of Medium: Online Resource
    ISSN: 0916-9636 , 1348-4214
    URL: Article
    DOI: 10.1038/s41440-024-01649-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2110941-2
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  • 4
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    High incidence of Aggregatibacter actinomycetemcomitansinfection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study
    Springer Science and Business Media LLC ; 2013
    In:  BMC Infectious Diseases Vol. 13, No. 1 ( 2013-12)
    Details
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2013-12)
    Abstract: Recent epidemiological studies suggest that periodontitis is a major risk factor for renal failure and cerebral infarction. The aim of this study was to evaluate the association among periodontitis, renal failure, and cerebral infarction, focusing on microbiological and immunological features. Methods Twenty-one patients treated with hemodialysis (HD) were enrolled in this study. They were 8 with diabetic nephropathy and 13 with non-diabetic nephropathy. Blood examination, periodontal examination, brain magnetic resonance image (MRI), and dental radiography were performed on all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontal pathogens, Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ), Porphyromonas gingivalis ( P. gingivalis ), and Prevotella intermedia ( P. intermedia ) using quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Results We found that the patients with diabetic nephropathy had more A. actinomycetemcomitans compared with non-diabetic nephropathy (P = 0.038) in dental plaque. Furthermore, the patients with diabetic nephropathy showed a significantly higher incidence of cerebral infarction compared with those with non-diabetic nephropathy (P = 0.029). Clinical oral and radiographic scores tended to be higher among patients in the diabetic nephropathy group than in the non-diabetic nephropathy group. Conclusions Periodontal pathogens, particularly A. actinomycetemcomitans , may play a role, at least a part, in the development of cerebral infarction in Japanese HD patients with diabetic nephropathy.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    URL: Article
    DOI: 10.1186/1471-2334-13-557
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2041550-3
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  • 5
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    Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia
    Springer Science and Business Media LLC ; 2017
    In:  BMC Cardiovascular Disorders Vol. 17, No. 1 ( 2017-12)
    Details
    In: BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2017-12)
    Type of Medium: Online Resource
    ISSN: 1471-2261
    URL: Article
    DOI: 10.1186/s12872-017-0703-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2059859-2
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  • 6
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    Abstract 1845: Adult Cardiac Progenitor Cells Promote Angiogenesis and Cardioprotection through Their Secreted Soluble Vcam-1
    Ovid Technologies (Wolters Kluwer Health) ; 2008
    In:  Circulation Vol. 118, No. suppl_18 ( 2008-10-28)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 118, No. suppl_18 ( 2008-10-28)
    Abstract: Although cardiac progenitor cells have been thought to be the promising source of cell therapy, the precise mechanisms of their paracrine action have not been fully elucidated. Since we observed that the transplantation of clonal expanded Sca-1 positive cardiac progenitor cells (cSca-1 cells) derived from adult murine heart by using cell sheet technique improved cardiac function of infarcted heart compared to adipose tissue derived mesenchymal cells (ATMC), we explored the secreted factors highly expressed in cSca-1 cells and identified that soluble VCAM-1 (sVCAM-1) was much abundant in cSca-1 cells compared to ATMC by using cytokine antibody array. cSca-1 cells-derived conditioned medium (CM) significantly enhanced endothelial migration and matrigel tube formation and these effects were abolished by knock down of VCAM-1 (Fold increase: control, 1.0; CM, 2.97 ± 0.21; siVCAM-1, 1.98 ± 0.09; siControl, 2.76 ± 0.05, p 〈 0.01), suggesting that cSca-1 cells promote angiogenesis via their secreted sVCAM-1. We next examined whether sVCAM-1 conferred direct protective effects on cardiomyocytes. We exposed cardiomyocytes to 0.2 mM H 2 O 2 in the absence or presence of sVCAM-1 or CM and examined cardiomyocyte viability by MTT assay. The exposure of cardiomyocytes to H 2 O 2 significantly induced the cell injury. Interestingly when pretreated with sVCAM-1 or CM, the cell damages of cardiomyocytes by H 2 O 2 were significantly reduced. However when pretreated with anti-VLA4 antibody, a principal coreceptor of sVCAM-1, CM mediated cell protected effect was completely inhibited (Fold increase: control, 1.0; anti-VLA4, 0.89 ± 0.33; sVCAM-1, 1.69 ± 0.27; CM, 2.08 ± 0.28; CM+anti-VLA4, 1.07 ± 0.07, p 〈 0.01), suggesting that a crucial role of the VLA4 in inducing survival of cardiomyocytes by CM. sVCAM-1 and CM induced phosphorylation of FAK, Akt, Erk and p38 MAPK in neonatal rat cardiomyocytes. When pretreated with wortmannin, SB203580 and PD98059, the cardioprotective effects of sVCAM-1 and CM significantly inhibited, suggesting that sVCAM-1 might protect cardiomyocytes from oxidative stress via integrated upregulation of Akt, Erk and p38MAPK. These findings suggest cardiac progenitor cells promote angiogenesis and cardioprotection through their secreted sVCAM-1.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.118.suppl_18.S_396-c
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2008
    detail.hit.zdb_id: 1466401-X
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  • 7
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    Abstract 12088: Low Computed Tomography Attenuation Value of Epicardial Fat is a Useful Marker for Coronary Stenosis
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Circulation Vol. 132, No. suppl_3 ( 2015-11-10)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 132, No. suppl_3 ( 2015-11-10)
    Abstract: Background: Epicardial fat volume (EFV) is recognized as an independent risk factor for coronary atherosclerosis. However, it remains unclear whether the computed tomography (CT) attenuation value of epicardial fat is associated with coronary stenosis. Methods: We analyzed the association of epicardial fat CT attenuation value (EFCTA) and EFV with obstructive coronary artery disease (CAD) in 355 patients (203 men; mean age, 68 ± 11 years) who underwent coronary CT angiography. EFCTA was calculated as the mean CT values of 5 regions of interest in epicardial fat. Results: A total of 200 (56.3%) patients were judged to have obstructive CAD. There was a strong correlation between EFCTA and EFV (R=-0.618, P 〈 0.001). EFCTA and EFV were significantly lower and higher, respectively, in patients with obstructive CAD (EFCTA, -93.0 HU [interquartile range, IR -101.0 - -84.6]; EFV, 110 mL [IR 83 - 146] ) than in those without (EFCTA, -88.8 HU [IR -95.6 - -79.4], P 〈 0.001; EFV, 89 mL [IR 68 - 122], P 〈 0.001). In logistic regression analysis using age and gender as covariates, the lowest EFCTA quartile ( 〈 -98.8 HU) was significantly associated with obstructive CAD (odds ratio [OR] 3.27, 95% confidence interval [CI] 1.68 - 6.34, P 〈 0.001). Age- and gender-adjusted logistic regression analysis showed that the highest EFV quartile (≥138 mL) had a significant association with obstructive CAD (OR 2.59, 95% CI 1.35 - 4.96, P=0.004). When age, gender, body mass index, smoking, estimated glomerular filtration rate (eGFR), hypertension, dyslipidemia, diabetes, and quartiles of EFCTA and EFV were used as independent valuables, the association of the lowest EFCTA quartile, but not the highest EFV quartile, with obstructive CAD remained statistically significant (OR 2.48, 95% CI 1.05 - 5.85, P=0.038). Conclusions: Low EFCTA was significantly associated with obstructive CAD, independent of traditional cardiovascular risk factors, suggesting that EFCTA may be a novel marker for assessment of CAD.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.132.suppl_3.12088
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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  • 8
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    Abstract P094: Weekly Variation of Circadian Peaks for the Onset of Acute Myocardial Infarction in the Working Population
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Circulation Vol. 125, No. suppl_10 ( 2012-03-13)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 125, No. suppl_10 ( 2012-03-13)
    Abstract: Variations in the incidence of acute myocardial infarction (AMI) during the day and week may differ among the subpopulations within the communities. It is well known that AMI onset shows characteristic circadian variations involving a definite morning peak and a vague nighttime peak: the former is often explained by biologic rhythms, while the latter by socioeconomic factors. Interestingly, we previously found that female patients aged 65 years or more showed a morning peak alone, whereas and male patients aged less than 65 years with an occupation and the habits of cigarette smoking and alcohol intake showed a nighttime peak alone. On the other hand, it is also reported that working population shows a weekly variation with an increased incidence for the AMI onset on Mondays. Accordingly, circadian variation for the onset of AMI could be influenced by each or combination of working status, gender, and the day of the week. However, there are few reports investigating circadian variation of AMI onset in relation with working status, gender and/or weekly variation. Therefore, we sought to investigate circadian variation patterns of AMI onset in relation with week variation according to gender and/or working status, especially in the working populations. From the registry database of the Osaka Acute Coronary Insufficiency Study (OACIS), a prospective observational study of AMI in Osaka area, Japan, a total of 7755 consecutive patients whose time of AMI onset was definitely identified between 1998 and 2009 were enrolled. The mean age of study population was 66+12 years old, 5872 (76%) were male, and 3364 (48%) had occupation. As previously reported, an increased incidence of AMI onset was observed in the morning and at the nighttime in overall populations. Interestingly, however, subgroup analysis revealed that the nighttime peak was completely attributable to the increase of nighttime onset on the weekend in the working subjects, especially working men, whereas the morning peak was common throughout the week with a peak on Monday in all other subgroups. As the weekend nighttime peak for AMI onset was not evident in other subgroups, this phenomenon may account for the social and/or economic reasons on the weekend in the working population. Although confirmation in other cohorts is required, this finding may help identify triggers of AMI and guide subjects to prevent an onset of AMI.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.125.suppl_10.AP094
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
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  • 9
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    Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Vol. 146, No. 16 ( 2022-10-18), p. 1225-1242
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. 16 ( 2022-10-18), p. 1225-1242
    Abstract: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand discovery of new genetic loci associated with VTE by using cross-ancestry genomic resources. Methods: We present new cross-ancestry meta-analyzed GWAS results involving up to 81 669 VTE cases from 30 studies, with replication of novel loci in independent populations and loci characterization through in silico genomic interrogations. Results: In our genetic discovery effort that included 55 330 participants with VTE (47 822 European, 6320 African, and 1188 Hispanic ancestry), we identified 48 novel associations, of which 34 were replicated after correction for multiple testing. In our combined discovery-replication analysis (81 669 VTE participants) and ancestry-stratified meta-analyses (European, African, and Hispanic), we identified another 44 novel associations, which are new candidate VTE-associated loci requiring replication. In total, across all GWAS meta-analyses, we identified 135 independent genomic loci significantly associated with VTE risk. A genetic risk score of the significantly associated loci in Europeans identified a 6-fold increase in risk for those in the top 1% of scores compared with those with average scores. We also identified 31 novel transcript associations in transcriptome-wide association studies and 8 novel candidate genes with protein quantitative-trait locus Mendelian randomization analyses. In silico interrogations of hemostasis and hematology traits and a large phenome-wide association analysis of the 135 GWAS loci provided insights to biological pathways contributing to VTE, with some loci contributing to VTE through well-characterized coagulation pathways and others providing new data on the role of hematology traits, particularly platelet function. Many of the replicated loci are outside of known or currently hypothesized pathways to thrombosis. Conclusions: Our cross-ancestry GWAS meta-analyses identified new loci associated with VTE. These findings highlight new pathways to thrombosis and provide novel molecules that may be useful in the development of improved antithrombosis treatments.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/CIRCULATIONAHA.122.059675
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 10
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    NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Circulation Vol. 147, No. 4 ( 2023-01-24), p. 338-355
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 147, No. 4 ( 2023-01-24), p. 338-355
    Abstract: Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of inflammation and its role in the stressed heart remain unclear. IL-1β (interleukin-1β) is a proinflammatory cytokine that causes cardiac hypertrophy and heart failure. Here, we show that neural signals activate the NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3) inflammasome for IL-1β production to induce adaptive hypertrophy in the stressed heart. Methods: C57BL/6 mice, knockout mouse strains for NLRP3 and P2RX7 (P2X purinoceptor 7), and adrenergic neuron-specific knockout mice for SLC17A9, a secretory vesicle protein responsible for the storage and release of ATP, were used for analysis. Pressure overload was induced by transverse aortic constriction. Various animal models were used, including pharmacological treatment with apyrase, lipopolysaccharide, 2′(3′)- O -(4-benzoylbenzoyl)-ATP, MCC950, anti–IL-1β antibodies, clonidine, pseudoephedrine, isoproterenol, and bisoprolol, left stellate ganglionectomy, and ablation of cardiac afferent nerves with capsaicin. Cardiac function and morphology, gene expression, myocardial IL-1β and caspase-1 activity, and extracellular ATP level were assessed. In vitro experiments were performed using primary cardiomyocytes and fibroblasts from rat neonates and human microvascular endothelial cell line. Cell surface area and proliferation were assessed. Results: Genetic disruption of NLRP3 resulted in significant loss of IL-1β production, cardiac hypertrophy, and contractile function during pressure overload. A bone marrow transplantation experiment revealed an essential role of NLRP3 in cardiac nonimmune cells in myocardial IL-1β production and cardiac phenotype. Pharmacological depletion of extracellular ATP or genetic disruption of the P2X7 receptor suppressed myocardial NLRP3 inflammasome activity during pressure overload, indicating an important role of ATP/P2X7 axis in cardiac inflammation and hypertrophy. Extracellular ATP induced hypertrophic changes of cardiac cells in an NLRP3- and IL-1β–dependent manner in vitro. Manipulation of the sympathetic nervous system suggested sympathetic efferent nerves as the main source of extracellular ATP. Depletion of ATP release from sympathetic efferent nerves, ablation of cardiac afferent nerves, or a lipophilic β-blocker reduced cardiac extracellular ATP level, and inhibited NLRP3 inflammasome activation, IL-1β production, and adaptive cardiac hypertrophy during pressure overload. Conclusions: Cardiac inflammation and hypertrophy are regulated by heart-brain interaction. Controlling neural signals might be important for the treatment of hypertensive heart disease.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/CIRCULATIONAHA.122.060860
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1466401-X
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