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Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh

Thayyil, Sudhin ; Pant, Stuti ; Montaldo, Paolo ; [weitere]

Elsevier BV ; 2021

In: The Lancet Global Health Vol. 9, No. 9 ( 2021-09), p. e1273-e1285

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In: The Lancet Global Health, Elsevier BV, Vol. 9, No. 9 ( 2021-09), p. e1273-e1285

Materialart: Online-Ressource

ISSN: 2214-109X

URL: Article

DOI: 10.1016/S2214-109X(21)00264-3

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2021

ZDB Id: 2723488-5

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Study of secondary hemo-phagocytic lympho-histiocytosis in children at a tertiary centre

Kantharajanna, Usha B. ; A., Pragalatha Kumar ; S., Sanjay K. ; [weitere]

Medip Academy ; 2021

In: International Journal of Contemporary Pediatrics Vol. 8, No. 11 ( 2021-10-25), p. 1855-

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In: International Journal of Contemporary Pediatrics, Medip Academy, Vol. 8, No. 11 ( 2021-10-25), p. 1855-

Kurzfassung: Background: Hemophagocytic lympho-histiocytosis (HLH) is fatal condition characterised by aggressive immune activation, dysregulation and up regulation of inflammatory cytokines leading to uncontrolled activation of T-cells, defective granule mediated cytotoxicity. HLH is classified into primary and secondary HLH.Methods: This is retrospective study of case-records of children who fulfilled criteria of HLH-2004 guidelines from November 2016 to November 2020.Results: Total number of patients with HLH was 33, excluding 4 cases of primary HLH, 29 cases met the inclusion criteria. 19 (65.5%) were children less than 5 years of age at the time of diagnosis. Six (20.7%) children were between 6 to 10 years and the rest 4 (13.8%) ten years. Average age at presentation was 4.93 years. Male to female ratio was 0.8 to 1. Fever was the chief complaint present in 29 (100%) of cases. Laboratory parameters showed anaemia, thrombocytopenia, hyper-ferritinemia and hypertriglyceridemia in all 29 (100%) cases. CRP elevated in 28 (96.6%) cases. Infections found in 29 (100%) of cases, bacteria in 19 (65.5%), viral in 10 (34.5%). Mortality seen in 11 (37.9%) cases. Average time of diagnosis from admission was 5.6 days. 4 children out of 11 had dengue as cause for secondary HLH and 4 had bacterial sepsis one each CMV, scrub typhus and SLE. Following factors affected the outcome by multivariate analysis, coagulopathy, elevated liver enzymes, bone marrow biopsy and immunosuppressive therapy.Conclusions: HLH should be considered in differential diagnosis of children with sepsis. High index of suspicion for HLH with early initiation of treatment should be considered for better outcome.

Materialart: Online-Ressource

ISSN: 2349-3291 , 2349-3283

URL: Article

DOI: 10.18203/2349-3291.ijcp20214159

Sprache: Unbekannt

Verlag: Medip Academy

Publikationsdatum: 2021

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Risk factors and outcome of Klebsiella sepsis in neonates

Kantharajanna, Usha B ; Shivanna Niranjan, Hunsanhalli ; Benakappa, Naveen ; [weitere]

Mansa STM Publishers ; 2020

In: Indian Journal of Child Health Vol. 7, No. 9 ( 2020-9-25), p. 366-370

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In: Indian Journal of Child Health, Mansa STM Publishers, Vol. 7, No. 9 ( 2020-9-25), p. 366-370

Materialart: Online-Ressource

ISSN: 2349-6118 , 2349-6126

URL: Article

DOI: 10.32677/IJCH.2020.v07.i09.003

Sprache: Unbekannt

Verlag: Mansa STM Publishers

Publikationsdatum: 2020

ZDB Id: 2808000-2

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